RUNX-IN-1

• 常用名: RUNX-IN-1
• 英文名: RUNX-IN-1
• CAS号: 2177285-35-5
• 分子量: 1524.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₇₁H₈₈Cl₂N₂₄O₁₁
• 熔点: N/A
• 闪点: N/A

RUNX-IN-1用途

RUNX-IN-1 Compound Conjugate 1) 与 RUNX 结合序列共价结合,并抑制 RUNX 蛋白与其靶位点的结合。RUNX-IN-1 诱导 p53 依赖性的细胞凋亡 (apoptosis),并抑制细胞生长。RUNX-IN-1 抑制 PANC-1 异种移植小鼠的肿瘤生长。

RUNX-IN-1名称

• 英文名: RUNX-IN-1

RUNX-IN-1生物活性

• 描述: RUNX-IN-1 Compound Conjugate 1) 与 RUNX 结合序列共价结合,并抑制 RUNX 蛋白与其靶位点的结合。RUNX-IN-1 诱导 p53 依赖性的细胞凋亡 (apoptosis),并抑制细胞生长。RUNX-IN-1 抑制 PANC-1 异种移植小鼠的肿瘤生长。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 靶点实验:

  RUNX[1]

• 参考文献:

  [1]. Hirose Y, et al. Anticancer Activities of DNA-Alkylating Pyrrole-Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells. J Med Chem. 2023 Sep 14;66(17):12059-12068.

RUNX-IN-1物理化学性质

• 分子式: C₇₁H₈₈Cl₂N₂₄O₁₁
• 分子量: 1524.52
• InChIKey: KEMUNUGWVPYFER-UHFFFAOYSA-N
• SMILES: CN(C)CCCNC(=O)c1cc(NC(=O)c2cc(NC(=O)c3cc(NC(=O)c4cc(NC(=O)CCCNC(=O)c5nc(NC(=O)c6nc(NC(=O)c7cc(NC(=O)c8nc(NC(=O)CCNC(=O)CCCc9ccc(N(CCCl)CCCl)cc9)cn8C)cn7C)cn6C)cn5C)cn4C)cn3C)cn2C)cn1C

RUNX-IN-1靶点实验

查看更多实验

实验名称：Induction of apoptosis in human PANC-1 cells assessed as increase in phosphorylated p... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366499

实验名称：Induction of apoptosis in human PANC-1 cells assessed as increase in phosphorylated p... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366500

实验名称：Induction of apoptosis in human PANC-1 cells assessed as suppression of BCL11A mRNA l... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366497

实验名称：Induction of apoptosis in human PANC-1 cells assessed as increase in phosphorylated p... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366498

实验名称：Induction of apoptosis in human PANC-1 cells assessed as late apoptotic cells at 3 uM... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366495

实验名称：Induction of apoptosis in human PANC-1 cells assessed as necrotic cells at 3 uM incub... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366496

实验名称：Induction of apoptosis in human PANC-1 cells assessed as viable cells at 3 uM incubat... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366493

实验名称：Induction of apoptosis in human PANC-1 cells assessed as early apoptotic cells at 3 u... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366494

实验名称：Cytotoxicity against human PANC-1 cells assessed as cell viability at 3 uM incubated ... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366491

实验名称：Cytotoxicity against human hTERT-HPNE cells assessed as cell viability at 3 uM incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5366492

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