氨酰基tRNA合成酶-IN-1

• 常用名: 氨酰基tRNA合成酶-IN-1
• 英文名: Aminoacyl tRNA synthetase-IN-1
• CAS号: 219931-45-0
• 分子量: 459.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₂₅N₇O₇S
• 熔点: N/A
• 闪点: N/A

氨酰基tRNA合成酶-IN-1用途

Aminoacyl tRNA synthetase-IN-1 是细菌中氨酰基 tRNA 合成酶 (aaRS) 的抑制剂。

氨酰基tRNA合成酶-IN-1名称

• 中文名: 氨酰基tRNA合成酶-IN-1
• 英文名: Aminoacyl tRNA synthetase-IN-1

氨酰基tRNA合成酶-IN-1生物活性

• 描述: Aminoacyl tRNA synthetase-IN-1 是细菌中氨酰基 tRNA 合成酶 (aaRS) 的抑制剂。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 靶点实验:

  aaRS[1]

• 参考文献:

  [1]. Vondenhoff GH, et al. Microcin C and albomycin analogues with aryl-tetrazole substituents as nucleobase isosters areselective inhibitors of bacterial aminoacyl tRNA synthetases but lack efficient uptake. Chembiochem. 2012 Sep 3;13(13):1959-69.

氨酰基tRNA合成酶-IN-1物理化学性质

• 分子式: C₁₆H₂₅N₇O₇S
• 分子量: 459.48
• InChIKey: ADKZHDGLJXVNIT-VBJYJYTRSA-N
• SMILES: CCC(C)C(N)C(=O)NS(=O)(=O)OCC1OC(n2cnc3c(N)ncnc32)C(O)C1O
• 储存条件: 2-8℃

氨酰基tRNA合成酶-IN-1靶点实验

查看更多实验

实验名称：Inhibition of Isoleucine-tRNA synthetase in wild type Escherichia coli S30 cell extra... 来源：ChEMBL 靶标：Isoleucine--tRNA ligase External Id：CHEMBL3271206

实验名称：Antibacterial activity against wild type Escherichia coli assessed as growth inhibiti... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL3271209

实验名称：Inhibition of ileRS in Escherichia coli BL21 (DE3) pLysS S30 extract over expressing ... 来源：ChEMBL 靶标：Isoleucine--tRNA ligase External Id：CHEMBL4394792

实验名称：Antibacterial activity against Kocuria rhizophila ATCC 9341 up to 100 uM after 18 to ... 来源：ChEMBL 靶标：Kocuria rhizophila External Id：CHEMBL4197615

实验名称：Inhibition of leuRS in Escherichia coli BL21 (DE3) pLysS S30 extract over expressing ... 来源：ChEMBL 靶标：Leucine--tRNA ligase External Id：CHEMBL4394793

实验名称：Antibacterial activity against Staphylococcus epidermidis RP62A up to 100 uM after 18... 来源：ChEMBL 靶标：Staphylococcus epidermidis External Id：CHEMBL4197614

实验名称：Inhibition of ileRS in Escherichia coli BL21 (DE3) pLysS S30 extract over expressing ... 来源：ChEMBL 靶标：Isoleucine--tRNA ligase External Id：CHEMBL4394794

实验名称：Antibacterial activity against Pseudomonas aeruginosa PAO1 up to 100 uM after 18 to 2... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4197617

实验名称：Immunosuppressive activity against human PBMC assessed as inhibition of allogenic mix... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL958132

实验名称：Inhibition of ileRS in Escherichia coli BL21 (DE3) pLysS S30 extract over expressing ... 来源：ChEMBL 靶标：Isoleucine--tRNA ligase External Id：CHEMBL4394795

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