PI3Kβ-IN-1

• 常用名: PI3Kβ-IN-1
• 英文名: PI3Kβ-IN-1
• CAS号: 2215098-77-2
• 分子量: 464.43
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₁₄F₂N₈
• 熔点: N/A
• 闪点: N/A

PI3Kβ-IN-1用途

PI3Kβ-IN-1(化合物(P)-14)是一种选择性口服活性PI3Kβ抑制剂,IC50为2nm[1]。

PI3Kβ-IN-1名称

• 英文名: PI3Kβ-IN-1

PI3Kβ-IN-1生物活性

• 描述: PI3Kβ-IN-1(化合物(P)-14)是一种选择性口服活性PI3Kβ抑制剂,IC50为2nm[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 靶点实验:

  IC50: 2 nM (PI3Kβ)[1]

• 参考文献:

  [1]. Perreault S, et al. Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif. ACS Med Chem Lett. 2020 Apr 13;11(6):1236-1243.

PI3Kβ-IN-1物理化学性质

• 分子式: C₂₅H₁₄F₂N₈
• 分子量: 464.43

PI3Kβ-IN-1靶点实验

查看更多实验

实验名称：Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619047

实验名称：Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619046

实验名称：Protein binding in Sprague-Dawley rat plasma at 1 mg/kg administered as iv infusion f... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619053

实验名称：Selectivity index, ratio of IC50 for human p110delta catalytic subunit/p85alpha to IC... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619041

实验名称：Selectivity index, ratio of IC50 for human full length p110alpha/p85alpha to IC50 for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619040

实验名称：Dissociation constant, acidic pKa of compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619043

实验名称：Selectivity index, ratio of IC50 for human full length p110gamma to IC50 for recombin... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619042

实验名称：Clearance in human hepatocytes at 1 uM measured up to 250 mins by UHPLC-HRMS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619045

实验名称：Genotoxicity in Salmonella typhimurium by Ames test 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619088

实验名称：Ocular toxicity in Beagle dog assessed as irreversible damage by measuring red conjuc... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4619079

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