RH1

• 常用名: RH1
• 英文名: RH1
• CAS号: 221635-42-3
• 分子量: 234.25100
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₄N₂O₃
• 熔点: N/A
• 闪点: N/A

RH1用途

RH1 (NSC 697726) 是一种有效的生物还原剂,在体外和体内具有显着的抗癌活性。

RH1名称

• 中文名: RH1
• 英文名: 2,5-di(aziridin-1-yl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone

RH1生物活性

• 描述: RH1 (NSC 697726) 是一种有效的生物还原剂,在体外和体内具有显着的抗癌活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 体外研究: 用RH1(50和100nM)处理NQ16细胞60和120分钟导致交联DNA显着增加(p <0.05)。 RH1在NQ16细胞中以时间和浓度依赖性方式诱导细胞凋亡[1]。
• 体内研究: RH1以剂量依赖性方式对无胸腺小鼠中生长的NQ16肿瘤表现出抗肿瘤活性。在治疗期结束后5天,RH1治疗(0.4mg/kg和0.2mg/kg)携带NQ16肿瘤的小鼠导致治疗组和对照之间肿瘤体积显着减少。低剂量RH1(0.1 mg/kg)也可导致治疗小鼠与对照组之间肿瘤体积显着减少[2]。
• 细胞实验: 将MDA468和NQ16细胞分别在50,100和500nM或10,50和100nM的RH1处理，在未补充的培养基中处理30,60或120分钟，然后吸出给药培养基，用PBS冲洗。 ，然后收获[1]。
• 动物实验: 小鼠[2]将携带双侧肿瘤的雌性无胸腺裸鼠随机分入对照组和每个细胞系7至8只动物的三个药物治疗组。每天将RH1（0.1mg / kg，0.2mg / kg或0.4mg / kg）注射到小鼠中连续5天（每天5天）[2]。
• 参考文献:

  [1]. Park MT, et al. The anti-tumour compound, RH1, causes mitochondria-mediated apoptosis by activating c-Jun N-terminal kinase. Br J Pharmacol. 2011 Jun;163(3):567-85.

  [2]. Dehn DL, et al. Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1. Clin Cancer Res. 2004 May 1;10(9):3147-55.

RH1物理化学性质

• 分子式: C₁₂H₁₄N₂O₃
• 分子量: 234.25100
• 精确质量: 234.10000
• PSA: 60.39000
• InChIKey: JKDLOGLNPDVUCX-UHFFFAOYSA-N
• SMILES: CC1=C(N2CC2)C(=O)C(CO)=C(N2CC2)C1=O

RH1靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum... 来源：The Scripps Research Institute Molecular Screening Center 靶标：transactivating tegument protein VP16 [Human herpesvirus 1] External Id：VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Luminescence-based cell-based high throughput confirmation assay for inhibitors of th... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor coactivator 1 isoform 1 [Homo sapiens] External Id：SRC1_INH_LUMI_1536_3X%INH CRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of NR3A 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1015-NR3A-Primary-Assay

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RH1英文别名

• RH1
• 2,5-diaziridin-1-yl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
• 2,5-diaziridinyl 1-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
• 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
• 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone
• RHI
• 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone