GluN2B receptor modulator-1

• 常用名: GluN2B receptor modulator-1
• 英文名: GluN2B receptor modulator-1
• CAS号: 2222010-71-9
• 分子量: 396.39
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₅F₃N₄O₂S
• 熔点: N/A
• 闪点: N/A

GluN2B receptor modulator-1用途

GluN2B受体调节剂-1是一种选择性GluN2B负变构调节剂,IC50值为31 nM。

GluN2B receptor modulator-1名称

• 英文名: GluN2B receptor modulator-1

GluN2B receptor modulator-1生物活性

• 描述: GluN2B受体调节剂-1是一种选择性GluN2B负变构调节剂,IC50值为31 nM。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> iGluR
• 参考文献:

  [1]. Chrovian CC, et al. Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders. J Med Chem. 2020 Sep 10;63(17):9181-9196.

GluN2B receptor modulator-1物理化学性质

• 分子式: C₁₇H₁₅F₃N₄O₂S
• 分子量: 396.39
• InChIKey: VBYDZMQKWHOANY-UHFFFAOYSA-N
• SMILES: Cn1c(=O)n(CC(=O)N2CCC2)c2cc(-c3ccc(C(F)(F)F)s3)cnc21

GluN2B receptor modulator-1靶点实验

查看更多实验

实验名称：Intrinsic clearance in rat liver microsomes at 1 uM after 5 to 60 mins in presence of... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4728833

实验名称：Intrinsic clearance in dog liver microsomes at 1 uM after 5 to 60 mins in presence of... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4728834

实验名称：Intrinsic clearance in human liver microsomes at 1 uM after 5 to 60 mins in presence ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4728832

实验名称：Standard cell-based calcium flux assay from US Patent US10617676: "Substituted 1H-imi... 来源：BindingDB 靶标：N/A External Id：BindingDB_9043_1

实验名称：Intrinsic clearance in cynomolgus monkey liver microsomes at 1 uM after 5 to 60 mins ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4728835

实验名称：Drug level in Sprague-Dawley rat brain hippocampus at 0.03 mg/kg, iv after 60 min by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4728825

实验名称：Drug level in Sprague-Dawley rat brain hippocampus at 0.03 mg/kg, iv after 120 min by... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4728826

实验名称：Drug level in Sprague-Dawley rat brain hippocampus at 0.03 mg/kg, iv after 30 min by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4728823

实验名称：Drug level in Sprague-Dawley rat brain cerebellum at 0.03 mg/kg, iv after 60 min by L... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4728824

实验名称：Ex vivo receptor occupancy at GluN2B in po dosed Sprague-Dawley rat assessed as 3-[3H... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4728829

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