ATX抑制剂1

• 常用名: ATX抑制剂1
• 英文名: ATX inhibitor 1
• CAS号: 2225892-70-4
• 分子量: 501.30
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₃Cl₂N₂O₆P
• 熔点: N/A
• 闪点: N/A

ATX抑制剂1用途

ATX inhibitor 1是有效的 ATX (IC50=1.23 nM, FS-3; 2.18 nM, bis-pNPP) 抑制剂。

ATX抑制剂1名称

• 中文名: ATX抑制剂1
• 英文名: ATX inhibitor 1

ATX抑制剂1生物活性

• 描述: ATX inhibitor 1是有效的 ATX (IC50=1.23 nM, FS-3; 2.18 nM, bis-pNPP) 抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 其他
• 靶点实验:

  IC50: 1.23 nM (FS-3) and 2.18 nM (bis-pNPP)[1]

• 参考文献:

  [1]. Balupuri A, et al. Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation. Eur J Med Chem. 2018 Mar 25;148:397-409.

ATX抑制剂1物理化学性质

• 分子式: C₂₁H₂₃Cl₂N₂O₆P
• 分子量: 501.30

ATX抑制剂1靶点实验

查看更多实验

实验名称：AUC in Sprague-Dawley rat at 2 mg/kg, iv administered as single bolus dose by HPLC-MS... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4197623

实验名称：Clearance in Sprague-Dawley rat at 2 mg/kg, iv administered as single bolus dose by H... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4197625

实验名称：Dose normalized AUC in Sprague-Dawley rat at 2 mg/kg, iv administered as single bolus... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4197624

实验名称：Inhibition of human ENPP2 using bis-pNPP as substrate measured every 10 secs for 10 m... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 External Id：CHEMBL4197619

实验名称：Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 External Id：CHEMBL4197618

实验名称：AUC in Sprague-Dawley rat at 10 mg/kg, iv administered as single bolus dose by HPLC-M... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4197631

实验名称：Terminal half life in Sprague-Dawley rat at 2 mg/kg, iv administered as single bolus ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4197630

实验名称：Clearance in Sprague-Dawley rat at 10 mg/kg, iv administered as single bolus dose by ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4197633

实验名称：Dose normalized AUC in Sprague-Dawley rat at 10 mg/kg, iv administered as single bolu... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4197632

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv administe... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4197626

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