ATG7-IN-2

• 常用名: ATG7-IN-2
• 英文名: ATG7-IN-2
• CAS号: 2226227-75-2
• 分子量: 376.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₁₆N₆O₇S
• 熔点: N/A
• 闪点: N/A

ATG7-IN-2用途

ATG7-IN-2(化合物1)是一种有效的ATG7抑制剂,IC50为0.089μM。ATG7-IN-2抑制自噬标记物LC3B【1】。

ATG7-IN-2名称

• 英文名: ATG7-IN-2

ATG7-IN-2生物活性

• 描述: ATG7-IN-2(化合物1)是一种有效的ATG7抑制剂,IC50为0.089μM。ATG7-IN-2抑制自噬标记物LC3B【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 自噬 >> 自噬
• 靶点实验:

  IC50: 0.089 ± 0.036 μM (ATG7), 0.335 ± 0.049 μM (Thioester), 2.6 μM (LC3B)[1]

• 参考文献:

  [1]. Huang SC, et al. Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115681.

ATG7-IN-2物理化学性质

• 分子式: C₁₁H₁₆N₆O₇S
• 分子量: 376.35

ATG7-IN-2靶点实验

查看更多实验

实验名称：Inhibition of recombinant His-tagged human ATG7 at 0.123 uM incubated for 105 mins in... 来源：ChEMBL 靶标：Ubiquitin-like modifier-activating enzyme ATG7 External Id：CHEMBL4418463

实验名称：Inhibition of ATG7 in human 293HEK cells assessed as inhibition of ATG7:ATG8 thioeste... 来源：ChEMBL 靶标：Ubiquitin-like modifier-activating enzyme ATG7 External Id：CHEMBL4730116

实验名称：Enzyme Assay from US Patent US10865208: "ATG7 inhibitors and the uses thereof" 来源：BindingDB 靶标：N/A External Id：BindingDB_9587_1

实验名称：Induction of autophagy in human H4 cells assessed as decrease in LC3B spot area by im... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4730110

实验名称：Antiproliferative activity against human H1650 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：NCI-H1650 External Id：CHEMBL4730107

实验名称：Inhibition of recombinant His-tagged human ATG7 incubated for 105 mins in presence of... 来源：ChEMBL 靶标：Ubiquitin-like modifier-activating enzyme ATG7 External Id：CHEMBL4730108

实验名称：Inhibition of recombinant His-tagged human ATG7 incubated for 105 mins in presence of... 来源：ChEMBL 靶标：Ubiquitin-like modifier-activating enzyme ATG7 External Id：CHEMBL4418462

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