AS-1763

• 常用名: AS-1763
• 英文名: AS-1763
• CAS号: 2227211-00-7
• 分子量: 578.64
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₃H₃₁FN₆O₃
• 熔点: N/A
• 闪点: N/A

AS-1763用途

AS-1763是一种有效、选择性、非共价和口服的布鲁顿酪氨酸激酶抑制剂(IC50=0.85 nM)。

AS-1763名称

• 英文名: AS-1763

AS-1763生物活性

• 描述: AS-1763是一种有效、选择性、非共价和口服的布鲁顿酪氨酸激酶抑制剂(IC50=0.85 nM)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> BTK
• 参考文献:

  [1]. Kawahata W, et al. Discovery of AS-1763: A Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton's Tyrosine Kinase. J Med Chem. 2021 Oct 14;64(19):14129-14141.

AS-1763物理化学性质

• 分子式: C₃₃H₃₁FN₆O₃
• 分子量: 578.64
• InChIKey: LJODJUIHONTDMR-UHFFFAOYSA-N
• SMILES: Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(C3=CCN(C4COC4)CC3)[nH]c2n1

AS-1763靶点实验

查看更多实验

实验名称：In vivo inhibition of autophosphorylation of BTK at Y223 in mouse at 7.5 to 30 mg/kg,... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL5054265

实验名称：Inhibition of BTK in BABL/c mouse blood assessed as reduction in BTK phosphorylation ... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL5054264

实验名称：Antitumor activity against human OCILY10 cells xenografted in SCID mouse assessed as ... 来源：ChEMBL 靶标：OCI-Ly10 External Id：CHEMBL5054259

实验名称：Antitumor activity against human OCILY10 cells xenografted in SCID mouse assessed as ... 来源：ChEMBL 靶标：OCI-Ly10 External Id：CHEMBL5054258

实验名称：Oral bioavailability in dog at 5 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5054257

实验名称：Oral bioavailability in rat at 15 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5054256

实验名称：Inhibition of BTK in BABL/c mouse blood assessed as reduction in BTK phosphorylation ... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL5054263

实验名称：Toxicity in SCID mouse harboring human OCILY10 cells harboring BTK C481S mutant knock... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5054262

实验名称：Antitumor activity against human ibrutinib-resistant BTK[C481S] knock-in OCILY10 cell... 来源：ChEMBL 靶标：OCI-Ly10 External Id：CHEMBL5054261

实验名称：Antitumor activity against human OCILY10 cells in SCID mouse assessed as tumor growth... 来源：ChEMBL 靶标：OCI-Ly10 External Id：CHEMBL5054260

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