IACS-8779 disodium

• 常用名: IACS-8779 disodium
• 英文名: IACS-8779 disodium
• CAS号: 2243079-27-6
• 分子量: 733.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₃N₉Na₂O₁₀P₂S₂
• 熔点: N/A
• 闪点: N/A

IACS-8779 disodium用途

IACS-8779二钠是一种高效的干扰素基因刺激剂(STING)激动剂,具有强大的全身抗肿瘤功效。IACS-8779二钠在体外显示出STING通路的强烈激活,在B16小鼠黑色素瘤模型中显示出优越的全身抗肿瘤反应[1]。

IACS-8779 disodium名称

• 英文名: IACS-8779 disodium

IACS-8779 disodium生物活性

• 描述: IACS-8779二钠是一种高效的干扰素基因刺激剂(STING)激动剂,具有强大的全身抗肿瘤功效。IACS-8779二钠在体外显示出STING通路的强烈激活,在B16小鼠黑色素瘤模型中显示出优越的全身抗肿瘤反应[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 刺
• 参考文献:

  [1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.

IACS-8779 disodium物理化学性质

• 分子式: C₂₁H₂₃N₉Na₂O₁₀P₂S₂
• 分子量: 733.52

IACS-8779 disodium靶点实验

查看更多实验

实验名称：Antitumor activity against mouse B16-OVA cells implanted in mouse assessed as tumour ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4400373

实验名称：Agonist activity at STING in human THP-1 cells assessed as stimulation of IRF3 pathwa... 来源：ChEMBL 靶标：Stimulator of interferon genes protein External Id：CHEMBL4400374

实验名称：Agonist activity at STING in mouse J774 cells assessed as stimulation of IRF3 pathway... 来源：ChEMBL 靶标：Stimulator of interferon genes protein External Id：CHEMBL4400375

实验名称：Agonist activity at STING in human THP-1 cells assessed as stimulation of IRF3 pathwa... 来源：ChEMBL 靶标：Stimulator of interferon genes protein External Id：CHEMBL4400376

实验名称：Antitumor activity against mouse B16-OVA cells implanted in mouse assessed as tumour ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4400377

实验名称：Antitumor activity against mouse B16-OVA cells implanted in mouse assessed as higher ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4400378

共6条，当前第1页，共1页

1