Sirt2-IN-6

• 常用名: Sirt2-IN-6
• 英文名: Sirt2-IN-6
• CAS号: 2243151-81-5
• 分子量: 502.59
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₆N₆O₃S
• 熔点: N/A
• 闪点: N/A

Sirt2-IN-6用途

Sirt2-IN-6(化合物24a)是Sirt2的有效和选择性抑制剂,IC50为0.815μM。Sirt2-IN-6可用于癌症研究[1]。

Sirt2-IN-6名称

• 英文名: Sirt2-IN-6

Sirt2-IN-6生物活性

• 描述: Sirt2-IN-6(化合物24a)是Sirt2的有效和选择性抑制剂,IC50为0.815μM。Sirt2-IN-6可用于癌症研究[1]。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
• 靶点实验:

  SIRT2:0.815 μM (IC50)

• 参考文献:

  [1]. Yang LL, et, al. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem. 2018 Jul 15;155:806-823.

Sirt2-IN-6物理化学性质

• 分子式: C₂₆H₂₆N₆O₃S
• 分子量: 502.59

Sirt2-IN-6靶点实验

查看更多实验

实验名称：Inhibition of SIRT2 in human NCI-H441 cells assessed as increase in acetylated alpha-... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-2 External Id：CHEMBL4156268

实验名称：Anti-invasive activity against human NCI-H441 cells after 48 hrs by crystal violet st... 来源：ChEMBL 靶标：NCI-H441 External Id：CHEMBL4156280

实验名称：Induction of apoptosis in human NCI-H441 cells assessed as early apoptotic cells at 3... 来源：ChEMBL 靶标：NCI-H441 External Id：CHEMBL4156275

实验名称：Induction of apoptosis in human NCI-H441 cells assessed as late apoptotic cells at 30... 来源：ChEMBL 靶标：NCI-H441 External Id：CHEMBL4156276

实验名称：Induction of apoptosis in human NCI-H441 cells assessed as necrotic cells at 30 uM af... 来源：ChEMBL 靶标：NCI-H441 External Id：CHEMBL4156277

实验名称：Inhibition of recombinant His-tagged SIRT2 (56 to 356 residues) (unknown origin) expr... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-2 External Id：CHEMBL4156262

实验名称：Antimigratory activity against human NCI-H441 cells assessed as reduction in wound cl... 来源：ChEMBL 靶标：NCI-H441 External Id：CHEMBL4156278

实验名称：Anticlonogenic activity against human NCI-H441 cells at 3 to 30 uM after 2 weeks by c... 来源：ChEMBL 靶标：NCI-H441 External Id：CHEMBL4156271

实验名称：Antiproliferative activity against human NCI-H441 cells assessed as reduction in EdU ... 来源：ChEMBL 靶标：NCI-H441 External Id：CHEMBL4156273

实验名称：Induction of apoptosis in human NCI-H441 cells assessed as live cells at 30 uM after ... 来源：ChEMBL 靶标：NCI-H441 External Id：CHEMBL4156274

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