P-gp调节剂1

• 常用名: P-gp调节剂1
• 英文名: P-gp modulator 1
• CAS号: 2249749-39-9
• 分子量: 689.02
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₁H₇₂N₂O₆
• 熔点: N/A
• 闪点: N/A

P-gp调节剂1用途

P-gp modulator 1 是一种高亲和力、口服有效的 p- 糖蛋白 (Pgp) 调节剂,可以逆转 Pgp 介导的多药抗性。

P-gp调节剂1名称

• 中文名: P-gp调节剂1
• 英文名: P-gp modulator 1

P-gp调节剂1生物活性

• 描述: P-gp modulator 1 是一种高亲和力、口服有效的 p- 糖蛋白 (Pgp) 调节剂,可以逆转 Pgp 介导的多药抗性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 跨膜转运 >> P-糖蛋白
• 靶点实验:

  P-glycoprotein

• 参考文献:

  [1]. Ren Q, et al. Design, synthesis, and discovery of ocotillol-type amide derivatives as orally available modulators of P-glycoprotein-mediated multidrug resistance. Eur J Med Chem. 2019 Jan 1;161:118-130.

P-gp调节剂1物理化学性质

• 分子式: C₄₁H₇₂N₂O₆
• 分子量: 689.02
• InChIKey: VDINNMXEKZJEKS-OVMOOWNWSA-N
• SMILES: CC(C)(C)OC(=O)NCCCCCC(=O)NC1CCC2(C)C(CCC3(C)C2CC(O)C2C(C4(C)CCC(C(C)(C)O)O4)CCC23C)C1(C)C

P-gp调节剂1靶点实验

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实验名称：Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potenti... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4326828

实验名称：Cell cycle arrest in human KBV cells assessed as accumulation at G2/M phase at 10 uM ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4326823

实验名称：Cell cycle arrest in human KBV cells assessed as accumulation at S phase at 10 uM aft... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4326822

实验名称：Cell cycle arrest in human KBV cells assessed as accumulation at G0/G1 phase at 10 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4326821

实验名称：Potentiation of paclitaxel-induced antitumor activity against human KBV cells xenogra... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4326836

实验名称：Stimulation of P-gp ATPase activity (unknown origin) assessed as increase in ATP cons... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4326835

实验名称：Antitumor activity against human KBV cells xenografted model assessed as reduction in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4739320

实验名称：Stimulation of P-gp ATPase activity (unknown origin) at 0.5 mM preincubated for 5 min... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4326834

实验名称：Inhibition of P-gp-mediated Rh-123 efflux in human KBV cells assessed as Rh-123 accum... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4326832

实验名称：Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potenti... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4326831

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