XSJ2-46

• 常用名: XSJ2-46
• 英文名: XSJ2-46
• CAS号: 2265911-12-2
• 分子量: 548.94
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₄ClF₃N₆O₃
• 熔点: N/A
• 闪点: N/A

XSJ2-46用途

XSJ2-46,5'-氨基 NI 类似物,是一种抗病毒剂。 XSJ2-46 具有抗 Zika 病毒活性。 XSJ2-46 对 RNA 依赖性 RNA 聚合酶 (RdRp) 具有抑制作用,IC50 值为 8.78 μM。

XSJ2-46名称

• 英文名: XSJ2-46

XSJ2-46生物活性

• 描述: XSJ2-46,5'-氨基 NI 类似物,是一种抗病毒剂。 XSJ2-46 具有抗 Zika 病毒活性。 XSJ2-46 对 RNA 依赖性 RNA 聚合酶 (RdRp) 具有抑制作用,IC50 值为 8.78 μM。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 靶点实验:

  IC50: 8.78 μM (RdRp)[1].

• 参考文献:

  [1]. Chen X, et al. Investigation of novel 5'-amino adenosine derivatives with potential anti-Zika virus activity. Eur J Med Chem. 2023 Oct 1;261:115852.

XSJ2-46物理化学性质

• 分子式: C₂₅H₂₄ClF₃N₆O₃
• 分子量: 548.94
• InChIKey: YXVLDZLVROXMQN-UMCMBGNQSA-N
• SMILES: OC1C(CNCc2ccc(C(F)(F)F)cc2)OC(n2cnc3c(NCc4cccc(Cl)c4)ncnc32)C1O

XSJ2-46靶点实验

查看更多实验

实验名称：Half-life in ICR mouse at 25 mg/kg, po administered as single dose and measured upto ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5636703

实验名称：Antiviral activity against Zika virus infected in golden hamster BHK cells assessed a... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5636704

实验名称：Tmax in ICR mouse at 25 mg/kg, po administered as single dose and measured upto 24 hr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5636705

实验名称：Cmax in ICR mouse at 25 mg/kg, po administered as single dose and measured upto 24 hr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5636706

实验名称：AUC (0 to t) in ICR mouse at 25 mg/kg, po administered as single dose and measured up... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5636707

实验名称：MRT in ICR mouse at 25 mg/kg, po administered as single dose and measured upto 24 hrs... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5636708

实验名称：Acute toxicity in A129 mouse assessed as animal death at 50 mg/kg, po measured after ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5636709

实验名称：Acute toxicity in A129 mouse assessed as animal death at 100 mg/kg, po measured after... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5636710

实验名称：Acute toxicity in A129 mouse assessed as animal death at 200 mg/kg, po measured after... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5636711

实验名称：Acute toxicity in po dosed ICR mouse assessed as lethal dose measured after 2 weeks 来源：ChEMBL 靶标：N/A External Id：CHEMBL5636712

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