依马普尼

• 常用名: 依马普尼
• 英文名: AC 5216
• CAS号: 226954-04-7
• 分子量: 401.461
• 密度: 1.3±0.1 g/cm3
• 沸点: 536.2±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₃N₅O₂
• 熔点: N/A
• 闪点: 278.1±30.1 °C
• 符号: GHS07
• 信号词: Warning

依马普尼用途

Emapunil(AC-5216;XBD-173)是转运蛋白TSPO(18 kDa)的配体。

依马普尼名称

• 中文名: 依马普尼
• 英文名: N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide

依马普尼生物活性

• 描述: Emapunil(AC-5216;XBD-173)是转运蛋白TSPO(18 kDa)的配体。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Costa B, et al. Translocator protein as a promising target for novel anxiolytics. Curr Top Med Chem. 2012;12(4):270-85.

  [2]. Rupprecht R, et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science. 2009 Jul 24;325(5939):490-3.

  [3]. Qiu ZK, et al. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus. Sci Rep. 2016 Nov 25;6:37345.

依马普尼物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 536.2±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₃N₅O₂
• 分子量: 401.461
• 闪点: 278.1±30.1 °C
• 精确质量: 401.185181
• PSA: 73.02000
• LogP: 3.14
• InChIKey: NBMBIEOUVBHEBM-UHFFFAOYSA-N
• SMILES: CCN(Cc1ccccc1)C(=O)Cn1c(=O)n(C)c2cnc(-c3ccccc3)nc21
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.624
• 储存条件: 2-8℃

依马普尼安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport

依马普尼靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Distribution coefficient, log D in octanol/phosphate buffer at pH 7.4 by shaking flas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL993539

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after... 来源：ChEMBL 靶标：Translocator protein External Id：CHEMBL2212410

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Lipophilicity, log D of the compound in octanol-phosphate buffer at pH 7.4 by shake f... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2212411

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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依马普尼英文别名

• AC-5216
• Emapunil
• N-Benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide
• UNII-OG837L732J
• XBD-173
• AC5216