AC 5216

Modify Date: 2024-01-04 14:16:53

AC 5216 structure	Common Name	AC 5216
	CAS Number	226954-04-7	Molecular Weight	401.461
	Density	1.3±0.1 g/cm3	Boiling Point	536.2±50.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₃N₅O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	278.1±30.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of AC 5216

Emapunil(AC-5216;XBD-173) is a translocator protein[TSPO (18 kDa)] ligand.IC50 value:Target: TSPO ligandXBD173 enhanced gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in rodents in the absence of sedation and tolerance development. XBD173 also exerted antipanic activity in humans and, in contrast to benzodiazepines, did not cause sedation or withdrawal symptoms [1]. The selective TSPO ligand, XBD173 (AC-5216, Emapunil), exerts anxiolytic effects not only in animal models, but also in human volunteers [2].

Name	N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide
Synonym	More Synonyms

Description	Emapunil(AC-5216;XBD-173) is a translocator protein[TSPO (18 kDa)] ligand.IC50 value:Target: TSPO ligandXBD173 enhanced gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in rodents in the absence of sedation and tolerance development. XBD173 also exerted antipanic activity in humans and, in contrast to benzodiazepines, did not cause sedation or withdrawal symptoms [1]. The selective TSPO ligand, XBD173 (AC-5216, Emapunil), exerts anxiolytic effects not only in animal models, but also in human volunteers [2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Costa B, et al. Translocator protein as a promising target for novel anxiolytics. Curr Top Med Chem. 2012;12(4):270-85. [2]. Rupprecht R, et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science. 2009 Jul 24;325(5939):490-3. [3]. Qiu ZK, et al. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus. Sci Rep. 2016 Nov 25;6:37345.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Costa B, et al. Translocator protein as a promising target for novel anxiolytics. Curr Top Med Chem. 2012;12(4):270-85.

[2]. Rupprecht R, et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science. 2009 Jul 24;325(5939):490-3.

[3]. Qiu ZK, et al. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus. Sci Rep. 2016 Nov 25;6:37345.

Density	1.3±0.1 g/cm3
Boiling Point	536.2±50.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₃N₅O₂
Molecular Weight	401.461
Flash Point	278.1±30.1 °C
Exact Mass	401.185181
PSA	73.02000
LogP	3.14
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.624
Storage condition	2-8℃

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport

AC-5216

9H-Purine-9-acetamide, N-ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-

Emapunil

N-Benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

UNII-OG837L732J

XBD-173

AC5216

DC Chemicals Limited
China
Product Name: Emapunil(AC-5216)
Price: $350.0/100mg $650.0/250mg $1300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $132/10mM*1mLinDMSO

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AC 5216

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