诃子鞣酸

• 常用名: 诃子鞣酸
• 英文名: Chebulagic acid
• CAS号: 23094-71-5
• 分子量: 954.661
• 密度: 2.1±0.1 g/cm3
• 沸点: 1610.6±65.0 °C at 760 mmHg
• 分子式: C₄₁H₃₀O₂₇
• 熔点: >300℃
• 闪点: 480.0±27.8 °C

诃子鞣酸用途

Chebulagic acid是一个从果实中提取出来的COX-LOX双重抑制剂。有抗炎和抗感染的效果。

诃子鞣酸名称

• 中文名: 诃子鞣质
• 英文名: 1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose
• 中文别名: 诃子鞣酸

诃子鞣酸生物活性

• 描述: Chebulagic acid是一个从果实中提取出来的COX-LOX双重抑制剂。有抗炎和抗感染的效果。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  天然产物 >> 酚类
• 参考文献:

  [1]. Kim HJ et al. Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells. Biomol Ther (Seoul). 2014 Jul;22(4):275-81.

  [2]. Liu Y et al. Chebulagic acid inhibits the LPS-induced expression of TNF-α and IL-1β in endothelial cells by suppressing MAPK activation. Exp Ther Med. 2015 Jul;10(1):263-268.

  [3]. Athira AP et al. Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor. Int J Vasc Med. 2013;2013:843897.

诃子鞣酸物理化学性质

• 密度: 2.1±0.1 g/cm3
• 沸点: 1610.6±65.0 °C at 760 mmHg
• 熔点: >300℃
• 分子式: C₄₁H₃₀O₂₇
• 分子量: 954.661
• 闪点: 480.0±27.8 °C
• 精确质量: 954.097473
• PSA: 447.09000
• LogP: 2.25
• InChIKey: HGJXAVROWQLCTP-JGPATRSISA-N
• SMILES: O=C(O)CC1C(=O)OC2C3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC2C(OC(=O)c2cc(O)c(O)c4c2C1C(O)C(=O)O4)C(OC(=O)c1cc(O)c(O)c(O)c1)O3
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.876
• 储存条件: -20°C

诃子鞣酸安全信息

• 危险品运输编码: NONH for all modes of transport

诃子鞣酸靶点实验

查看更多实验

实验名称：Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition ... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL964367

实验名称：Inhibition of Saccharomyces cerevisiae fatty acid synthase 来源：ChEMBL 靶标：N/A External Id：CHEMBL943598

实验名称：Antifungal activity against Cryptococcus neoformans ATCC 90113 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL943600

实验名称：Antifungal activity against Candida albicans ATCC 90028 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL943599

实验名称：Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition ... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL964363

实验名称：Antioxidant activity assessed as DPPH radical scavenging activity 来源：ChEMBL 靶标：N/A External Id：CHEMBL951646

实验名称：Inhibition of xanthine oxidase assessed as conversion of xanthine to uric acid incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3074592

实验名称：Selectivity index, ratio of CC50 for human Huh7.5 cells to EC50 for Hepatitis C virus... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1942348

实验名称：Antimicrobial activity against Candida albicans at 100 ug after 24 hr by disk diffusi... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL3074593

实验名称：Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition ... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL964364

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诃子鞣酸英文别名

• Chebulagic acid
• [(4R,5S,7R,25S,26R,29S,30S,31S)-13,14,15,18,19,20,31,35,36-Nonahydroxy-2,10,23,28,32-pentaoxo-5-[(3,4,5-trihydroxybenzoyl)oxy]-3,6,9,24,27,33-hexaoxaheptacyclo[28.7.1.0.0.0.0 .0]octatriaconta-1(38),11,13,15,17,19,21,34,36-nonaen-29-yl]acetic acid
• CHEBULAGIC ACID(RG)