Apovincaminol

• 常用名: Apovincaminol
• 英文名: Apovincaminol
• CAS号: 23173-26-4
• 分子量: 308.42
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₄N₂O
• 熔点: N/A
• 闪点: N/A

Apovincaminol用途

Vin-C01是一种有效的胰腺β细胞保护剂,EC50为0.22µM。Vin-C01有效促进β细胞存活,保护β细胞免受STZ诱导的凋亡。Vin-C01可用于2型糖尿病研究[1]。

Apovincaminol名称

• 英文名: eburnamenine-14-ylmethanol

Apovincaminol生物活性

• 描述: Vin-C01是一种有效的胰腺β细胞保护剂,EC50为0.22µM。Vin-C01有效促进β细胞存活,保护β细胞免受STZ诱导的凋亡。Vin-C01可用于2型糖尿病研究[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 心血管疾病
• 靶点实验:

  EC50: 0.22 µM (pancreatic β-cells)[1]

• 参考文献:

  [1]. Wang J, et al. Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic β-cells protective agents for the treatment of type 2 diabetes mellitus. Eur J Med Chem. 2020 Feb 15;188:111976.

Apovincaminol物理化学性质

• 分子式: C₂₀H₂₄N₂O
• 分子量: 308.42
• 精确质量: 308.18900
• PSA: 28.40000
• LogP: 3.51540

Apovincaminol靶点实验

查看更多实验

实验名称：Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells at 10 ... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4683514

实验名称：Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells assess... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4683517

实验名称：Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells assess... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4683516

实验名称：Activation of AKT in STZ-induced rat INS-1 832/13 cells assessed as increase in Akt p... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4683519

实验名称：Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells assess... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4683518

实验名称：Activation of AKT in STZ-induced rat INS-1 832/13 cells assessed as increase in Akt p... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4683521

实验名称：Activation of PI3K/Akt signalling pathway in STZ-induced rat INS-1 832/13 cells asses... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4683510

实验名称：Potency index, ratio of vincamine EC50 to test compound EC50 for cytoprotective activ... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4683513

实验名称：Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induc... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4683512

实验名称：Cytoprotective activity against STZ-induced rat INS-1 832/13 cells assessed as increa... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4683531

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Apovincaminol英文别名

• ((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthen-10-yl)-methanol