HBV-IN-22

更新时间：2025-08-26 18:41:00

HBV-IN-22用途

HBV-IN-22(化合物LC5f)是一种HBV DNA复制抑制剂,对野生型和耐药HBV株的IC50值分别为0.71µM和0.84µM【1】。

英文名	HBV-IN-22

描述	HBV-IN-22(化合物LC5f)是一种HBV DNA复制抑制剂,对野生型和耐药HBV株的IC50值分别为0.71µM和0.84µM【1】。
相关类别	研究领域 >> 感染信号通路 >> 抗感染 >> HBV 信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
靶点实验	IC50: 0.71 µM (wild-type HBV DNA replication), 0.84 µM (drug resistant HBV DNA replication)[1]
参考文献	[1]. Qiu J, et al. Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents. Eur J Med Chem. 2020 Nov 1;205:112581.

分子式	C₂₆H₂₉N₃O₂S₂
分子量	479.66

实验名称：Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assesse...
来源：ChEMBL
靶标：HepG2 2.2.15
External Id：CHEMBL5158574

实验名称：Inhibition of capsid protein in wild type Hepatitis B virus infected in human HepG2.2...
来源：ChEMBL
靶标：Capsid protein
External Id：CHEMBL4352902

实验名称：Inhibition of capsid protein in lamivudine/entecavir-resistant Hepatitis B virus harb...
来源：ChEMBL
靶标：Capsid protein
External Id：CHEMBL4352901

实验名称：Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for capsid protei...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4352900

实验名称：Inhibition of capsid protein in Hepatitis B virus infected in human HepG2.2.15 cells ...
来源：ChEMBL
靶标：Capsid protein
External Id：CHEMBL4352898

实验名称：Cytotoxicity against human HepG2.2.15 cells assessed as cell viability measured after...
来源：ChEMBL
靶标：HepG2 2.2.15
External Id：CHEMBL4352897

实验名称：Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells ass...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5158577

实验名称：Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assesse...
来源：ChEMBL
靶标：HepG2 2.2.15
External Id：CHEMBL5158576

实验名称：Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for capsid protei...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4352908

实验名称：Selectivity index, ratio of CC50 for human HepG2.2.2.15 cells to IC50 for Hepatitis B...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5158578

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