Darizmetinib

• 常用名: Darizmetinib
• 英文名: Darizmetinib
• CAS号: 2369583-33-3
• 分子量: 457.45
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₇F₂N₅O₃S
• 熔点: N/A
• 闪点: N/A

Darizmetinib用途

Darizmetinib是丝裂原活化蛋白激酶激酶(MAP2K)的抑制剂[1][2]。

Darizmetinib名称

• 英文名: Darizmetinib

Darizmetinib生物活性

• 描述: Darizmetinib是丝裂原活化蛋白激酶激酶(MAP2K)的抑制剂[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
• 参考文献:

  [1]. Praefke B, et al. Preparation of pyrazolopyridines as protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death: World Intellectual Property Organization, WO2019149738. 2019-08-08.

  [2]. WHO Drug Information-World Health Organization (WHO).

Darizmetinib物理化学性质

• 分子式: C₂₁H₁₇F₂N₅O₃S
• 分子量: 457.45

Darizmetinib靶点实验

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实验名称：Selectivity index, ratio of inhibition of full length human MKK7 (M1 to R419 residues... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4742622

实验名称：Selectivity index, ratio of inhibition of B-raf (unknown origin) to inhibition of par... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4742623

实验名称：Inhibition of partial length human MKK4 (S84 to D399 residues) expressed in mammalian... 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 4 External Id：CHEMBL4742620

实验名称：Selectivity index, ratio of inhibition of full length human JNK1 (M1 to Q384 residues... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4742621

实验名称：Inhibition of MEKK2 (unknown origin) using casein as substrate in presence of [gamma-... 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 4 External Id：CHEMBL4742626

实验名称：Inhibition of MEKK2- induced activation of MKK4/(unknown origin) using JNK1 as substr... 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 4 External Id：CHEMBL4742624

实验名称：Inhibition of MKK4/(unknown origin) using JNK1 as substrate in presence of [gamma-33P... 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 4 External Id：CHEMBL4742625

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