J-1048

• 常用名: J-1048
• 英文名: J-1048
• CAS号: 2374772-60-6
• 分子量: 460.55
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₁₇FN₆S₂
• 熔点: N/A
• 闪点: N/A

J-1048用途

J-1048是一种激活素受体样激酶5(ALK5)抑制剂。J-1048可通过明确阻断TGF-β/Smad信号通路抑制TAA诱导的小鼠肝纤维化[1]。

J-1048名称

• 英文名: J-1048

J-1048生物活性

• 描述: J-1048是一种激活素受体样激酶5(ALK5)抑制剂。J-1048可通过明确阻断TGF-β/Smad信号通路抑制TAA诱导的小鼠肝纤维化[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 蛋白酪氨酸激酶 >> ALK
• 参考文献:

  [1]. Yang HX, et al. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation. Bioorg Chem. 2023 Oct;139:106723.

J-1048物理化学性质

• 分子式: C₂₃H₁₇FN₆S₂
• 分子量: 460.55
• InChIKey: TVWMUKRZUMLJMU-UHFFFAOYSA-N
• SMILES: Cc1cccc(-c2nn(CC(=S)Nc3cccc(F)c3)cc2-c2ccc3nsnc3c2)n1

J-1048靶点实验

查看更多实验

实验名称：Inhibition of ALK5 in human LX2 cells assessed as reduction in TGFbeta-induced COL1A1... 来源：ChEMBL 靶标：TGF-beta receptor type-1 External Id：CHEMBL4361681

实验名称：Inhibition of ALK5 in human LX2 cells assessed as reduction in TGFbeta-induced ACTA2 ... 来源：ChEMBL 靶标：TGF-beta receptor type-1 External Id：CHEMBL4361680

实验名称：Inhibition of ALK5 in human LX2 cells assessed as reduction in TGFbeta-induced alphaS... 来源：ChEMBL 靶标：TGF-beta receptor type-1 External Id：CHEMBL4361679

实验名称：Inhibition of ALK5 in human LX2 cells assessed as reduction in TGFbeta-induced collag... 来源：ChEMBL 靶标：TGF-beta receptor type-1 External Id：CHEMBL4361678

实验名称：Inhibition of ALK5 in human LX2 cells assessed as reduction in TGFbeta-induced alphaS... 来源：ChEMBL 靶标：TGF-beta receptor type-1 External Id：CHEMBL4361675

实验名称：Inhibition of ALK5 in human LX2 cells assessed as reduction in TGFbeta-induced collag... 来源：ChEMBL 靶标：TGF-beta receptor type-1 External Id：CHEMBL4361674

实验名称：Cytotoxicity against human LX2 cells assessed as reduction in cell viability at 4 to ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4361673

实验名称：Inhibition of TGFbetaR1 (unknown origin) 来源：ChEMBL 靶标：TGF-beta receptor type-1 External Id：CHEMBL5515535

实验名称：Selectivity index, ratio of IC50 for human recombinant untagged p38alpha expressed in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4361672

实验名称：Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL4361671

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