ZN-c3

• 常用名: ZN-c3
• 英文名: ZN-c3
• CAS号: 2376146-48-2
• 分子量: 526.63
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₄N₈O₂
• 熔点: N/A
• 闪点: N/A

ZN-c3用途

ZN-c3是一种口服活性、高效和选择性Wee1抑制剂(IC50=3.9 nM)。锌-c3可用于癌症研究[1]。

ZN-c3名称

• 英文名: ZN-c3

ZN-c3生物活性

• 描述: ZN-c3是一种口服活性、高效和选择性Wee1抑制剂(IC50=3.9 nM)。锌-c3可用于癌症研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> WEE1
• 靶点实验:

  IC50: 3.9 nM (Wee1)[1]

• 体外研究: H23c细胞中的ZN-c3 IC50为103 nM[1]。
• 体内研究: 锌-c3(80 mg/kg；p.o.；28天)作为一种单一药物,在80 mg/kg时可以有效地缩小肿瘤[1]。锌-c3在狗PK研究中显示出良好的暴露和生物利用度[1]。
• 参考文献:

  [1]. Huang PQ, et al. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer [published online ahead of print, 2021 Aug 23]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01121.

ZN-c3物理化学性质

• 分子式: C₂₉H₃₄N₈O₂
• 分子量: 526.63
• InChIKey: OXTSYWDBUVRXFF-GDLZYMKVSA-N
• SMILES: C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1ccc2c(n1)C(O)(CC)CC2
• 储存条件: -20°C

ZN-c3靶点实验

查看更多实验

实验名称：Antitumor activity against human SW837 cells assessed as inhibition of cell growth at... 来源：ChEMBL 靶标：SW837 External Id：CHEMBL5359234

实验名称：Antitumor activity against human LoVo cells xenografted in female BALB/c nude mouse a... 来源：ChEMBL 靶标：LoVo External Id：CHEMBL5517207

实验名称：Antitumor activity against human NCI-H358 cells assessed as inhibition of cell growth... 来源：ChEMBL 靶标：NCI-H358 External Id：CHEMBL5359231

实验名称：Inhibition of Wee1 in human U2OS cells assessed as reduction in CDK1 phosphorylation ... 来源：ChEMBL 靶标：Wee1-like protein kinase External Id：CHEMBL5517206

实验名称：Synergistic antitumor activity against human NCI-H358 cells assessed as inhibition of... 来源：ChEMBL 靶标：NCI-H358 External Id：CHEMBL5359232

实验名称：Antiproliferative activity against human LoVo cells assessed as inhibition of cell gr... 来源：ChEMBL 靶标：LoVo External Id：CHEMBL5517205

实验名称：Synergistic antitumor activity against human MIA PaCa-2 cells assessed as inhibition ... 来源：ChEMBL 靶标：MIA PaCa-2 External Id：CHEMBL5359229

实验名称：Antitumor activity against human MIA PaCa-2 cells assessed as inhibition of cell grow... 来源：ChEMBL 靶标：MIA PaCa-2 External Id：CHEMBL5359228

实验名称：Synergistic antitumor activity against human NCI-H23 cells assessed as inhibition of ... 来源：ChEMBL 靶标：NCI-H23 External Id：CHEMBL5359226

实验名称：Antitumor activity against human NCI-H23 cells assessed as inhibition of cell growth ... 来源：ChEMBL 靶标：NCI-H23 External Id：CHEMBL5359224

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