EB-42486

• 常用名: EB-42486
• 英文名: EB-42486
• CAS号: 2390475-81-5
• 分子量: 414.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₂N₈O
• 熔点: N/A
• 闪点: N/A

EB-42486用途

EB-42486是一种新型、高效、高选择性的G2019S-LRRK2抑制剂(IC50<0.2nm)。

EB-42486名称

• 英文名: EB-42486

EB-42486生物活性

• 描述: EB-42486是一种新型、高效、高选择性的G2019S-LRRK2抑制剂(IC50<0.2nm)。
• 相关类别:
  信号通路 >> 自噬 >> LRRK2
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63(23):14821-14839.

EB-42486物理化学性质

• 分子式: C₂₂H₂₂N₈O
• 分子量: 414.46

EB-42486靶点实验

查看更多实验

实验名称：Clearance in CD-1 mouse at 0.5 mg/kg, iv measured at 0.25 to 12 hrs by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5246769

实验名称：MRT in CD-1 mouse at 2 mg/kg, po measured at 0.25 to 12 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5246768

实验名称：Oral bioavailability in CD-1 mouse at 2 mg/kg measured at 0.25 to 12 hrs by LC-MS/MS ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5246770

实验名称：Half life in CD-1 mouse at 0.5 mg/kg, iv measured at 0.25 to 12 hrs by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5246765

实验名称：Inhibition of LRRK2 G2019S mutant (unknown origin) using LRRKtide as substrate pre-in... 来源：ChEMBL 靶标：Leucine-rich repeat serine/threonine-protein kinase 2 External Id：CHEMBL5369083

实验名称：Tmax in CD-1 mouse at 2 mg/kg, po measured at 0.25 to 12 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5246764

实验名称：Selectivity ratio of IC50 for LRRK2 WT (unknown origin) to IC50 for LRRK2 G2019S muta... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5369084

实验名称：MRT in CD-1 mouse at 0.5 mg/kg, iv measured at 0.25 to 12 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5246767

实验名称：Half life in CD-1 mouse at 2 mg/kg, po measured at 0.25 to 12 hrs by LC-MS/MS analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5246766

实验名称：AUC in CD-1 mouse at 2 mg/kg, po measured at 0.25 to 12 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5246761

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