p38-α MAPK-IN-4

• 常用名: p38-α MAPK-IN-4
• 英文名: p38-α MAPK-IN-4
• CAS号: 2396754-57-5
• 分子量: 341.20
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₃BrN₂O
• 熔点: N/A
• 闪点: N/A

p38-α MAPK-IN-4用途

p38-αMAPK-IN-4(化合物69)是一种选择性p38αMAPK抑制剂,IC50为1.5µM。p38-αMAPK-IN-4可快速且强烈地阻止体内机械性痛觉超敏(MA)的发展【1】。

p38-α MAPK-IN-4名称

• 英文名: p38-α MAPK-IN-4

p38-α MAPK-IN-4生物活性

• 描述: p38-αMAPK-IN-4(化合物69)是一种选择性p38αMAPK抑制剂,IC50为1.5µM。p38-αMAPK-IN-4可快速且强烈地阻止体内机械性痛觉超敏(MA)的发展【1】。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点实验:

  p38α MAPK:1.5 μM (IC50)

• 参考文献:

  [1]. Visseq A, et al. Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia. Eur J Med Chem. 2020 Feb 1;187:111917.

p38-α MAPK-IN-4物理化学性质

• 分子式: C₁₇H₁₃BrN₂O
• 分子量: 341.20

p38-α MAPK-IN-4靶点实验

查看更多实验

实验名称：Anti-allodynic activity in complete freund's adjuvant-induced rat inflammatory pain m... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4707485

实验名称：Inhibition of p38 alpha (unknown origin) assessed as residual activity at 1 uM relati... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL4843971

实验名称：Anti-allodynic activity in complete freund's adjuvant-induced rat inflammatory pain m... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4843970

实验名称：Anti-allodynic activity in complete freund's adjuvant-induced rat inflammatory pain m... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4707488

实验名称：Inhibition of p38alpha MAPK (unknown origin) assessed as residual activity at 10 uM 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL4707491

实验名称：Inhibition of p38 alpha (unknown origin) at 1 uM relative to control 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL4843973

实验名称：Anti-allodynic activity in constriction injury-induced rat neuropathic mechanic allod... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4707490

实验名称：Inhibition of p38 alpha (unknown origin) 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL4843972

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