OM-1700

• 常用名: OM-1700
• 英文名: OM-1700
• CAS号: 2406276-78-4
• 分子量: 458.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₃FN₆O₂
• 熔点: N/A
• 闪点: N/A

OM-1700用途

OM-1700是一种有效的tankyrase抑制剂,对tankyrase 1和tankyrase 2的IC50分别为127和14 nM。OM-1700降低结肠癌细胞系COLO 320DM(GI50=650 nM)中的细胞生长[1]。

OM-1700名称

• 英文名: OM-1700

OM-1700生物活性

• 描述: OM-1700是一种有效的tankyrase抑制剂,对tankyrase 1和tankyrase 2的IC50分别为127和14 nM。OM-1700降低结肠癌细胞系COLO 320DM(GI50=650 nM)中的细胞生长[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> PARP
  信号通路 >> 细胞周期/DNA损伤 >> PARP
• 靶点实验:

  TNKS1:127 nM (IC50)

  TNKS2:14 nM (IC50)

• 体外研究: OM-153在细胞(HEK293)WNT/β-连环蛋白信号报告试验中显示出抑制(IC50=19 nM)[1]。
• 参考文献:

  [1]. Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949.

OM-1700物理化学性质

• 分子式: C₂₅H₂₃FN₆O₂
• 分子量: 458.49
• InChIKey: ZBRBBDJXHBEGHX-UHFFFAOYSA-N
• SMILES: CCOc1ccc(-c2nnc(C3CC(NC(=O)c4ccccn4)C3)n2-c2ccccc2F)nc1

OM-1700靶点实验

查看更多实验

实验名称：Metabolic stability in mouse liver microsomes assessed as intrinsic clearance measure... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5030387

实验名称：Metabolic stability in human liver microsomes assessed as intrinsic clearance measure... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5030386

实验名称：Intrinsic clearance in human hepatocytes assessed per million cells at 3 uM measured ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618665

实验名称：Efflux ratio of apparent permeability in human Caco-2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL5030385

实验名称：Intrinsic clearance in dog hepatocytes assessed per million cells at 3 uM measured af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618667

实验名称：Intrinsic clearance in mouse hepatocytes assessed per million cells at 3 uM measured ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618666

实验名称：Plasma protein binding in mouse by LC-MS/MS based equlibrium dialysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5030390

实验名称：Intrinsic clearance in cynomolgus monkey hepatocytes assessed per million cells at 3 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618669

实验名称：Stability in mouse plasma assessed as half life 来源：ChEMBL 靶标：N/A External Id：CHEMBL5030389

实验名称：Intrinsic clearance in rat hepatocytes assessed per million cells at 3 uM measured af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618668

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