Anticancer agent 57

• 常用名: Anticancer agent 57
• 英文名: Anticancer agent 57
• CAS号: 2408017-71-8
• 分子量: 378.29
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₁Cl₂NO₂
• 熔点: N/A
• 闪点: N/A

Anticancer agent 57用途

抗癌剂57(化合物14)可有效抑制MDA-MB-231、MDA-MB-468和MCF-7细胞系,IC50s为6.43～8.00μM。抗癌剂57诱导细胞周期阻滞并显著促进细胞凋亡。抗癌剂57抑制移植MADMB-231细胞的裸鼠肿瘤生长。抗癌剂57可用于研究三阴性乳腺癌(TNBC)[1]。

Anticancer agent 57名称

• 英文名: Anticancer agent 57

Anticancer agent 57生物活性

• 描述: 抗癌剂57(化合物14)可有效抑制MDA-MB-231、MDA-MB-468和MCF-7细胞系,IC50s为6.43～8.00μM。抗癌剂57诱导细胞周期阻滞并显著促进细胞凋亡。抗癌剂57抑制移植MADMB-231细胞的裸鼠肿瘤生长。抗癌剂57可用于研究三阴性乳腺癌(TNBC)[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 靶点实验:

  IC50: 8.00 ± 0.07 μM in MDA-MB-231, 7.30 ± 0.04 μM in MDA-MB-468, 6.43 ± 0.18 μM in MCF-7[1]

• 参考文献:

  [1]. Elkhalifa D, et al. Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer. Eur J Med Chem. 2020;187:111954.

Anticancer agent 57物理化学性质

• 分子式: C₂₀H₂₁Cl₂NO₂
• 分子量: 378.29

Anticancer agent 57靶点实验

查看更多实验

实验名称：Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse a... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4338720

实验名称：Antiinvasive activity in human MCF7 cells assessed as reduction in 10% FBS-induced ce... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4338718

实验名称：Antiinvasive activity in human MDA-MB-468 cells assessed as reduction in 10% FBS-indu... 来源：ChEMBL 靶标：MDA-MB-468 External Id：CHEMBL4338716

实验名称：Toxicity in athymic nude mouse xenografted with human MDA-MB-231 cells assessed as ef... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4338715

实验名称：Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse a... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4338714

实验名称：Inhibition of tumor growth in human MDA-MB-231 cells xenografted in nude mouse 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4338713

实验名称：Antiangiogenic activity in Leghorn chicken fertilized egg chorioallantoic membrane as... 来源：ChEMBL 靶标：Chorioallantoic membrane External Id：CHEMBL4338703

实验名称：Up regulation of E-cadherin level in human MCF7 cells up to 10 uM by Western blot ana... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4338702

实验名称：Up regulation of pan-cadherin level in human MCF7 cells up to 10 uM by Western blot a... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4338701

实验名称：Down regulation of FAK level in human MDA-MB-231 cells up to 10 uM by Western blot an... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4338700

共44条，当前第1页，共5页

1

2

3

4

5