Antitumor agent-59

• 常用名: Antitumor agent-59
• 英文名: Antitumor agent-59
• CAS号: 2409952-04-9
• 分子量: 770.78
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₃H₃₆F₂N₆O₆
• 熔点: N/A
• 闪点: N/A

Antitumor agent-59用途

抗肿瘤剂-59(化合物13b)是一种有效的抗肿瘤剂。抗肿瘤药物-59有效抑制HCT116细胞的增殖和迁移。抗肿瘤药物-59诱导HCT116细胞凋亡,并将细胞周期阻滞在G2/M期【1】。

Antitumor agent-59名称

• 英文名: Antitumor agent-59

Antitumor agent-59生物活性

• 描述: 抗肿瘤剂-59(化合物13b)是一种有效的抗肿瘤剂。抗肿瘤药物-59有效抑制HCT116细胞的增殖和迁移。抗肿瘤药物-59诱导HCT116细胞凋亡,并将细胞周期阻滞在G2/M期【1】。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 体外研究: 抗肿瘤剂-59(化合物13b)(72 h)对HCT116、MCF-7、A549和HUVEC细胞显示出抗肿瘤活性,IC50值分别为0.032±0.0071、0.20±0.020、0.73±0.12和0.58±0.15μM【1】。
• 参考文献:

  [1]. Liang H, et al. Discovery of novel bis-evodiamine derivatives with potent antitumor activity. Bioorg Med Chem. 2022 Jul 1;65:116793.

Antitumor agent-59物理化学性质

• 分子式: C₄₃H₃₆F₂N₆O₆
• 分子量: 770.78

Antitumor agent-59靶点实验

查看更多实验

实验名称：Induction of apoptosis in human HCT-116 cells at 0.05 uM incubated for 48 hrs by Anne... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148292

实验名称：Induction of apoptosis in human HCT-116 cells at 0.1 uM incubated for 48 hrs by Annex... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148293

实验名称：Induction of cell cycle arrest in human HCT-116 cells assessed as increase in Cyclin ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148286

实验名称：Induction of cell cycle arrest in human HCT-116 cells assessed as reduction in Cdc25c... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148287

实验名称：Induction of apoptosis in human HCT-116 cells assessed as increase in p53 protein exp... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148282

实验名称：Induction of apoptosis in human HCT-116 cells assessed as increase in cytochrome C pr... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148283

实验名称：Induction of apoptosis in human HCT-116 cells assessed as reduction in cytochrome C p... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148284

实验名称：Induction of apoptosis in human HCT-116 cells assessed as reduction in p53 protein ex... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148285

实验名称：Inhibition of cell migration of human HCT-116 cells at 0.01 to 0.15 uM incubated for ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148278

实验名称：Induction of apoptosis in human HCT-116 cells at 0.05 to 0.25 uM incubated for 48 hrs... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5148279

共24条，当前第1页，共3页

1

2

3