UR-MB108

• 常用名: UR-MB108
• 英文名: UR-MB108
• CAS号: 2412461-98-2
• 分子量: 666.77
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₀H₃₈N₆O₄
• 熔点: N/A
• 闪点: N/A

UR-MB108用途

UR-MB108(化合物57)是一种有效的选择性ABCG2(BCRP)抑制剂,IC50为79 nM。UR-MB108在血浆中是稳定的。

UR-MB108名称

• 英文名: UR-MB108

UR-MB108生物活性

• 描述: UR-MB108(化合物57)是一种有效的选择性ABCG2(BCRP)抑制剂,IC50为79 nM。UR-MB108在血浆中是稳定的。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 跨膜转运 >> BCRP
• 靶点实验:

  IC50: 79 nM (ABCG2 (BCRP))[1]

• 参考文献:

  [1]. Frauke Antoni, et al. Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP). Eur J Med Chem. 2020 Apr 1;191:112133.

UR-MB108物理化学性质

• 分子式: C₄₀H₃₈N₆O₄
• 分子量: 666.77
• InChIKey: KQTJIUOOFLJRAY-UHFFFAOYSA-N
• SMILES: CCC(=O)c1ccc(-c2cn(-c3ccc(CCN4CCc5cc(OC)c(OC)cc5C4)cc3)nn2)cc1NC(=O)c1ccc2ccccc2n1

UR-MB108靶点实验

查看更多实验

实验名称：Kinetic solubility of compound in PBS at pH 7.4 measured after 2 hrs by LC/MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4734595

实验名称：Thermodynamic solubility of compound in PBS at pH 7.4 measured after 24 hrs by shake-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4734596

实验名称：Inhibition of ABCB1 in human KB-V1 cells assessed as accumulation of substrate calcei... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4734586

实验名称：Inhibition of human ABCG2 in human MCF7/Topo cells assessed as accumulation of substr... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL4734584

实验名称：Cytotoxicity against human MCF7/Topo cells assessed as reduction in cell viability up... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4685397

实验名称：Inhibition of human ABCG2 in human MCF7/Topo cells assessed as accumulation of substr... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL4734585

实验名称：Inhibition of ABCG2 in human MCF7/Topo cells assessed as potentiation of topotecan-in... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL4685396

实验名称：Inhibition of human ABCC1 expressed in MDCK-MRP1 cells assessed as accumulation of su... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4734588

实验名称：Inhibition of human ABCC1 transfected in MDCK2-MRP1 cells up to 100 uM using calcein-... 来源：ChEMBL 靶标：Multidrug resistance-associated protein 1 External Id：CHEMBL4685387

实验名称：Activation of ABCB1 ATPase activity (unknown origin) expressed in baculovirus infecte... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4685390

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