Antitubercular agent-20

• 常用名: Antitubercular agent-20
• 英文名: Antitubercular agent-20
• CAS号: 2413124-92-0
• 分子量: 572.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₂F₆N₄O₃S
• 熔点: N/A
• 闪点: N/A

Antitubercular agent-20用途

抗结核剂-20(化合物2d)是一种口服活性抗结核剂。抗结核药物-20对MTB H37Rv和MDR-MTB菌株表现出优异的活性(MIC：＜0.016µg/ml)。抗结核药物-20在BALB/c小鼠中具有低细胞毒性和良好的耐受性[1]。

Antitubercular agent-20名称

• 英文名: Antitubercular agent-20

Antitubercular agent-20生物活性

• 描述: 抗结核剂-20(化合物2d)是一种口服活性抗结核剂。抗结核药物-20对MTB H37Rv和MDR-MTB菌株表现出优异的活性(MIC：＜0.016µg/ml)。抗结核药物-20在BALB/c小鼠中具有低细胞毒性和良好的耐受性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Wang A, et al. Identification of benzothiazinones containing 2-benzyl-2,7-diazaspiro[3.5]nonane moieties as new antitubercular agents. Eur J Med Chem. 2020 Aug 15;200:112409.

Antitubercular agent-20物理化学性质

• 分子式: C₂₅H₂₂F₆N₄O₃S
• 分子量: 572.52

Antitubercular agent-20靶点实验

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实验名称：Oral bioavailability in BALB/c mouse at 12.5 mg/kg measured upto 24 hrs by HPLC analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4687274

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assess... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4687261

实验名称：Antimycobacterial activity against multidrug resistance Mycobacterium tuberculosis 16... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4687263

实验名称：Antimycobacterial activity against multidrug resistance Mycobacterium tuberculosis 16... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4687262

实验名称：Acute toxicity in BALB/c mouse assessed as mouse survival at 2 g/kg, po observed cont... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4687265

实验名称：Cytotoxicity against African green monkey Vero cells 来源：ChEMBL 靶标：Vero External Id：CHEMBL4687264

实验名称：Half life in BALB/c mouse at 2.5 mg/kg, iv measured upto 24 hrs by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4687267

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in BALB/... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4687266

实验名称：Tmax in BALB/c mouse at 12.5 mg/kg, po measured upto 24 hrs by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4687269

实验名称：Half life in BALB/c mouse at 12.5 mg/kg, po measured upto 24 hrs by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4687268

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