Adenylyl cyclase type 2 agonist-1

• 常用名: Adenylyl cyclase type 2 agonist-1
• 英文名: Adenylyl cyclase type 2 agonist-1
• CAS号: 2414908-52-2
• 分子量: 550.78
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₁₇BrClNO₅
• 熔点: N/A
• 闪点: N/A

Adenylyl cyclase type 2 agonist-1用途

腺苷酸环化酶2型激动剂-1(化合物73)是腺苷酸循环酶2型(AC2)的有效激动剂,EC50为90 nM。腺苷酸环化酶2型激动剂-1抑制白细胞介素-6的表达,使其成为抗呼吸道疾病的潜在先导化合物[1]。

Adenylyl cyclase type 2 agonist-1名称

• 英文名: Adenylyl cyclase type 2 agonist-1

Adenylyl cyclase type 2 agonist-1生物活性

• 描述: 腺苷酸环化酶2型激动剂-1(化合物73)是腺苷酸循环酶2型(AC2)的有效激动剂,EC50为90 nM。腺苷酸环化酶2型激动剂-1抑制白细胞介素-6的表达,使其成为抗呼吸道疾病的潜在先导化合物[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷酸环化酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Guowei Xu, et al. The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation. Eur J Med Chem. 2020 Apr 1;191:112115.

Adenylyl cyclase type 2 agonist-1物理化学性质

• 分子式: C₂₇H₁₇BrClNO₅
• 分子量: 550.78

Adenylyl cyclase type 2 agonist-1靶点实验

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实验名称：Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as incre... 来源：ChEMBL 靶标：Adenylate cyclase type 2 External Id：CHEMBL4685439

实验名称：Agonist activity at recombinant human AC5 expressed in HEK293 cells assessed as incre... 来源：ChEMBL 靶标：Adenylate cyclase type 5 External Id：CHEMBL4685441

实验名称：Agonist activity at recombinant human AC1 expressed in HEK293 cells assessed as incre... 来源：ChEMBL 靶标：Adenylate cyclase type 1 External Id：CHEMBL4685440

实验名称：Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as incre... 来源：ChEMBL 靶标：Adenylate cyclase type 2 External Id：CHEMBL4685443

实验名称：Agonist activity at recombinant human AC8 expressed in HEK293 cells assessed as incre... 来源：ChEMBL 靶标：Adenylate cyclase type 8 External Id：CHEMBL4685442

实验名称：Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as reduc... 来源：ChEMBL 靶标：Adenylate cyclase type 2 External Id：CHEMBL4685445

实验名称：Potency index, ratio of forskolin EC50 to test compound EC50 for agonist activity at ... 来源：ChEMBL 靶标：Adenylate cyclase type 2 External Id：CHEMBL4685444

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