Benz-AP

更新时间：2026-08-23 15:34:32

Benz-AP用途

Benz AP是一种有效的光敏剂。Benz AP产生单线态氧,与hCES2(人类羧酸酯酶2)活性呈负相关。在低hCES2环境下,Benz AP对癌细胞显示出较高的光细胞毒性。在TPE(双光子激发)时,Benz AP产生ROS并杀死癌细胞和肿瘤球体[1]。

英文名	Benz-AP

描述	Benz AP是一种有效的光敏剂。Benz AP产生单线态氧,与hCES2(人类羧酸酯酶2)活性呈负相关。在低hCES2环境下,Benz AP对癌细胞显示出较高的光细胞毒性。在TPE(双光子激发)时,Benz AP产生ROS并杀死癌细胞和肿瘤球体[1]。
相关类别	研究领域 >> 癌症信号通路 >> 蛋白酪氨酸激酶 >> ROS
参考文献	[1]. Kailass K, et al. Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence. J Med Chem. 2022 Jun 14.

分子式	C₂₀H₁₃NO₂
分子量	299.32

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来源：ChEMBL
靶标：PANC-1
External Id：CHEMBL5136333

实验名称：Drug uptake in human PANC-1 cells at 0.5 to 20 uM after 3 hrs under 900 nm light irra...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5136365

实验名称：Induction of ROS production in human PANC-1 cells at 20 uM incubated for 3 hrs under ...
来源：ChEMBL
靶标：PANC-1
External Id：CHEMBL5136334

实验名称：Induction of ROS production in human MCF7 cells at 20 uM incubated for 3 hrs under 41...
来源：ChEMBL
靶标：MCF7
External Id：CHEMBL5136335

实验名称：Induction of cell death in human PANC-1 cells assessed as PAPR1 cleavage at 20 uM aft...
来源：ChEMBL
靶标：PANC-1
External Id：CHEMBL5136360

实验名称：Induction of ROS production in DBPS at pH 7.4 assessed as DCF production at 20 uM upo...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5136362

实验名称：Induction of singlet oxygen production assessed as singlet oxygen quantum yield at 20...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5136363

实验名称：Antitumor activity against human PANC-1 tumor spheroids at 20 uM after 1 hr under dar...
来源：ChEMBL
靶标：PANC-1
External Id：CHEMBL5136358

实验名称：Antitumor activity against human PANC-1 tumor spheroids at 20 uM preincubated for 3 h...
来源：ChEMBL
靶标：PANC-1
External Id：CHEMBL5136359

实验名称：Induction of apoptosis in human PANC-1 cells assessed as membrane decomposition at 20...
来源：ChEMBL
靶标：PANC-1
External Id：CHEMBL5136352

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