BChE-IN-7

• 常用名: BChE-IN-7
• 英文名: BChE-IN-7
• CAS号: 2416910-85-3
• 分子量: 336.43
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₄N₂O₂
• 熔点: N/A
• 闪点: N/A

BChE-IN-7用途

BChE-IN-7(化合物13)是一种有效、选择性、BBB穿透和可逆的乙酰胆碱酯酶和BChE抑制剂,IC50为0.06μM(BChE)。BChE-IN-7可以保护神经元样细胞免受有毒Aβ物种的侵害[1]。

BChE-IN-7名称

• 英文名: BChE-IN-7

BChE-IN-7生物活性

• 描述: BChE-IN-7(化合物13)是一种有效、选择性、BBB穿透和可逆的乙酰胆碱酯酶和BChE抑制剂,IC50为0.06μM(BChE)。BChE-IN-7可以保护神经元样细胞免受有毒Aβ物种的侵害[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 疼痛
• 靶点实验:

  IC50: 0.06 μM (BChE)[1]

• 参考文献:

  [1]. Košak U,et al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282.

BChE-IN-7物理化学性质

• 分子式: C₂₁H₂₄N₂O₂
• 分子量: 336.43

BChE-IN-7靶点实验

查看更多实验

实验名称：Cytotoxicity against human HepG2 cells at 50 uM incubated for 48 hrs by MTT assay 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4769586

实验名称：Effective permeability of compound at 200 uM measured after 4 hrs by PAMPA-BBB assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4769587

实验名称：Inhibition of HFIP-pretreated human amyloid beta (1 to 42) self aggregation at 10 uM ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4769584

实验名称：Cytotoxicity against human SH-SY5Y cells at 20 uM incubated for 48 hrs by MTT assay 来源：ChEMBL 靶标：SH-SY5Y External Id：CHEMBL4769585

实验名称：Reversible inhibition of human AChE using acetylthiocholine iodide as substrate prein... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL4769590

实验名称：Reversible inhibition of human BuChE using butyrylthiocholine iodide as substrate pre... 来源：ChEMBL 靶标：Cholinesterase External Id：CHEMBL4769591

实验名称：Inhibition of human recombinant microsomal MAO-A expressed in baculovirus-infected BT... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL4769589

实验名称：Non-time dependent inhibition of human AChE using acetylthiocholine iodide as substra... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL4769592

实验名称：Non-time dependent inhibition of human BuChE using butyrylthiocholine iodide as subst... 来源：ChEMBL 靶标：Cholinesterase External Id：CHEMBL4769593

实验名称：Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated wit... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL4769582

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