NBTIs-IN-6

• 常用名: NBTIs-IN-6
• 英文名: NBTIs-IN-6
• CAS号: 2422893-97-6
• 分子量: 498.50
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₇FN₄O₆
• 熔点: N/A
• 闪点: N/A

NBTIs-IN-6用途

NBTIs-IN-6是一种具有一定抗菌活性的细菌拓扑异构酶抑制剂。其中,耐氟喹诺酮MRSA的MIC90为2μg/mL[1]。

NBTIs-IN-6名称

• 英文名: NBTIs-IN-6

NBTIs-IN-6生物活性

• 描述: NBTIs-IN-6是一种具有一定抗菌活性的细菌拓扑异构酶抑制剂。其中,耐氟喹诺酮MRSA的MIC90为2μg/mL[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
  研究领域 >> 感染
• 参考文献:

  [1]. Antony Okumu, et al. Novel bacterial topoisomerase inhibitors derived from isomannide. Eur J Med Chem. 2020 Aug 1;199:112324.

NBTIs-IN-6物理化学性质

• 分子式: C₂₅H₂₇FN₄O₆
• 分子量: 498.50
• InChIKey: QWVOWTQCAWDAIT-LVEBQJTPSA-N
• SMILES: COc1ccc2ncc(F)c(CCC3(O)COC4C(NCc5cc6c(cn5)OCCO6)COC43)c2n1

NBTIs-IN-6靶点实验

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实验名称：Activation of recombinant human Nav1.5 late expressed in human HEK293 cells assessed ... 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL4769922

实验名称：Activation of recombinant human Nav1.5 late expressed in human HEK293 cells assessed ... 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL4769923

实验名称：Inhibition of recombinant human Nav1.5 late expressed in human HEK293 cells at 100 uM... 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL4769920

实验名称：Activation of recombinant human Nav1.5 late expressed in human HEK293 cells assessed ... 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL4769921

实验名称：Inhibition of recombinant human full length Nav1.2 expressed in CHO-K1 cells at 100 u... 来源：ChEMBL 靶标：Sodium channel protein type 2 subunit alpha External Id：CHEMBL4769926

实验名称：Inhibition of recombinant human full length 5HT2B expressed in CHO-K1 cells at 100 uM... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B External Id：CHEMBL4769927

实验名称：Inhibition of recombinant human full length histamine H2 receptor expressed in CHO-K1... 来源：ChEMBL 靶标：Histamine H2 receptor External Id：CHEMBL4769924

实验名称：Inhibition of recombinant human full length Norepinephrine transporter expressed in d... 来源：ChEMBL 靶标：Sodium-dependent noradrenaline transporter External Id：CHEMBL4769925

实验名称：Inhibition of recombinant human Cav1.2 expressed in human HEK293 cells at 100 uM meas... 来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1C External Id：CHEMBL4769914

实验名称：Inhibition of recombinant human Nav1.5 expressed in human HEK293 cells at 3 uM measur... 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL4769915

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