PI5P4Kα-IN-1

• 常用名: PI5P4Kα-IN-1
• 英文名: PI5P4Kα-IN-1
• CAS号: 2428737-31-7
• 分子量: 363.43
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₇N₃O₂S
• 熔点: N/A
• 闪点: N/A

PI5P4Kα-IN-1用途

PI5P4Kα-IN-1(化合物13)是一种PI5P4K抑制剂(PI5P4Kα和PI5P4Kβ的IC50:2和9.4μM)。PI5P4Kα-IN-1可用于癌症、代谢和免疫疾病的研究[1]。

PI5P4Kα-IN-1名称

• 英文名: PI5P4Kα-IN-1

PI5P4Kα-IN-1生物活性

• 描述: PI5P4Kα-IN-1(化合物13)是一种PI5P4K抑制剂(PI5P4Kα和PI5P4Kβ的IC50:2和9.4μM)。PI5P4Kα-IN-1可用于癌症、代谢和免疫疾病的研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Manz TD, et al. Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. J Med Chem. 2020 May 14;63(9):4880-4895.

PI5P4Kα-IN-1物理化学性质

• 分子式: C₂₀H₁₇N₃O₂S
• 分子量: 363.43
• InChIKey: KKMZWHRTQLNOCF-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)Nc1ccc(-c2cncc(-c3cccc4[nH]ccc34)c2)cc1

PI5P4Kα-IN-1靶点实验

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实验名称：Inhibition of GST-tagged recombinant PI5P4Kalpha (unknown origin) incubated for 1 hr ... 来源：ChEMBL 靶标：Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha External Id：CHEMBL4406333

实验名称：Inhibition of human ACVR2A expressed in baculovirus expression system 来源：ChEMBL 靶标：Activin receptor type-2A External Id：CHEMBL4406350

实验名称：Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr i... 来源：ChEMBL 靶标：Phosphatidylinositol 5-phosphate 4-kinase type-2 beta External Id：CHEMBL4406334

实验名称：Lipophilicity, logD of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL4406335

实验名称：Induction of stabilization of PI5P4Kalpha in HEK293T cells at 1 to 15 uM incubated fo... 来源：ChEMBL 靶标：Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha External Id：CHEMBL4406336

实验名称：Induction of stabilization of PI5P4Kbeta in HEK293T cells at 1 to 15 uM incubated for... 来源：ChEMBL 靶标：Phosphatidylinositol 5-phosphate 4-kinase type-2 beta External Id：CHEMBL4406337

实验名称：Permeability of the compound by PAMPA method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4406338

实验名称：Stability in rat liver microsomes at 1 uM in presence of NADPH regeneration system in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4406339

实验名称：Inhibition of PI5P4Kgamma (unknown origin) at 1 uM by KINOMEscan analysis 来源：ChEMBL 靶标：Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma External Id：CHEMBL5045820

实验名称：Inhibition of human ACVR2B expressed in baculovirus expression system 来源：ChEMBL 靶标：Activin receptor type-2B External Id：CHEMBL4406345

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