MNK/PIM-IN-1

• 常用名: MNK/PIM-IN-1
• 英文名: MNK/PIM-IN-1
• CAS号: 2430792-91-7
• 分子量: 486.54
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₇FN₆O₂
• 熔点: N/A
• 闪点: N/A

MNK/PIM-IN-1用途

MNK/PIM-IN-1是一种创新的双MNK/PIM抑制剂,具有良好的药代动力学特征。

MNK/PIM-IN-1名称

• 英文名: MNK/PIM-IN-1

MNK/PIM-IN-1生物活性

• 描述: MNK/PIM-IN-1是一种创新的双MNK/PIM抑制剂,具有良好的药代动力学特征。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> 皮姆
• 参考文献:

  [1]. Han Y, et al. Optimization of 4,6-Disubstituted Pyrido[3,2-d]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth. J Med Chem. 2021 Sep 23;64(18):13719-13735.

MNK/PIM-IN-1物理化学性质

• 分子式: C₂₇H₂₇FN₆O₂
• 分子量: 486.54

MNK/PIM-IN-1靶点实验

查看更多实验

实验名称：Intrinsic clearance in human liver microsomes preincubated for 10 mins followed by NA... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828328

实验名称：Intrinsic clearance in rat liver microsomes preincubated for 10 mins followed by NADP... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828329

实验名称：Antitumor activity against human MOLM-13 cells xenografted in NOD/SCID mouse assessed... 来源：ChEMBL 靶标：MOLM-13 External Id：CHEMBL4828326

实验名称：Metabolic stability in rat liver microsomes assessed as half life preincubated for 10... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828327

实验名称：Drug concentration in Sprague Dawley rat at 2 mg/kg, iv measured after 24 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828330

实验名称：Metabolic stability in human liver microsomes assessed as half life preincubated for ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828320

实验名称：Toxicity in NOD/SCID mouse xenografted with human MOLM-13 cells assessed as abnormal ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828321

实验名称：Toxicity in NOD/SCID mouse xenografted with human MOLM-13 cells assessed as abnormal ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828318

实验名称：Toxicity in NOD/SCID mouse xenografted with human MOLM-13 cells assessed as abnormal ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828319

实验名称：Antitumor activity against human MOLM-13 cells xenografted in NOD/SCID mouse assessed... 来源：ChEMBL 靶标：MOLM-13 External Id：CHEMBL4828324

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