KTX-497

更新时间：2025-11-28 11:13:53

KTX-497用途

KTX-497是一种口服活性IRAK4降解剂,DC50值为3nM。KTX-497可用于肿瘤学研究[1]。

英文名	KTX-497

描述	KTX-497是一种口服活性IRAK4降解剂,DC50值为3nM。KTX-497可用于肿瘤学研究[1]。
相关类别	研究领域 >> 癌症信号通路 >> 免疫及炎症 >> IRAK 信号通路 >> 蛋白酪氨酸激酶 >> IRAK
靶点实验	IRAK4:3 nM (DC50)
体外研究	KTX-497对IRAK4具有活性,DC50值为3nM[1]。
体内研究	KTX-497(口服；10 mg/kg)影响口服吸收[1]。动物模型：大鼠[1]剂量：10 mg/kg给药：口服结果：大鼠PO PK(10 mg/kg)KTX-497%F 17 AUC(μM*hr)1.4
参考文献	[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

分子式	C₄₅H₄₉F₃N₈O₆
分子量	854.92

实验名称：Plasma protein binding in Sprague-Dawley rat at 1 uM by UPLC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525813

实验名称：Oral bioavailability in rat at 10 mg/kg by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525810

实验名称：AUC in rat at 10 mg/kg, po by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525807

实验名称：Half life in rat at 2 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525806

实验名称：Volume of distribution at steady state in rat at 2 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525805

实验名称：Clearance in rat at 2 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525804

实验名称：Metabolic stability in rat liver microsomes assessed as intrinsic clearance at 1 uM m...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525802

实验名称：Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525801

实验名称：Passive permeability of the compound in wild type MDCK cells across apical to basolat...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525800

实验名称：Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by Cell...
来源：ChEMBL
靶标：OCI-Ly10
External Id：CHEMBL5525799

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