EGFR-IN-69

• 常用名: EGFR-IN-69
• 英文名: EGFR-IN-69
• CAS号: 2433837-65-9
• 分子量: 658.64
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₁H₃₇Cl₂N₇O₃S
• 熔点: N/A
• 闪点: N/A

EGFR-IN-69用途

EGFR-IN-69(化合物17g)是一种有效的EGFR抑制剂,对EGFR 858R/T790M/C797S、EGFR 858/T790M和EGFR 19DEL/T790M/C797 S的IC50值分别为4.3、6.6和25.6nM。EGFR-IN-69可用于非小细胞肺癌(NSCLC)研究[1]。

EGFR-IN-69名称

• 英文名: EGFR-IN-69

EGFR-IN-69生物活性

• 描述: EGFR-IN-69(化合物17g)是一种有效的EGFR抑制剂,对EGFR 858R/T790M/C797S、EGFR 858/T790M和EGFR 19DEL/T790M/C797 S的IC50值分别为4.3、6.6和25.6nM。EGFR-IN-69可用于非小细胞肺癌(NSCLC)研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 靶点实验:

  EGFR L858R/T790M/C797S:4.3 ± 0.9 nM (IC50)

  EGFRL858R/T790M:6.6 ± 0.8 nM (IC50)

  EGFRdel19 T790M C797S:25.6 ± 7.5 nM (IC50)

  EGFRWT:816.0 ± 82 nM (IC50)

• 参考文献:

  [1]. Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858.

EGFR-IN-69物理化学性质

• 分子式: C₃₁H₃₇Cl₂N₇O₃S
• 分子量: 658.64

EGFR-IN-69靶点实验

查看更多实验

实验名称：Cytotoxicity against mouse IL-3 dependent BaF3 cells assessed as inhibition of cell g... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5165821

实验名称：Antiproliferative activity against mouse BaF3 cells stably expressing EGFR L858R/T790... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5165820

实验名称：Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) by ELISA 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL5165817

实验名称：Inhibition of EGFR 19 del/T790M/C797S mutant (unknown origin) by ELISA 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL5165816

实验名称：Inhibition of wild type EGFR (unknown origin) by ELISA 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL5165819

实验名称：Inhibition of EGFR L858R/T790M mutant (unknown origin) by ELISA 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL5165818

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