PI3K/mTOR Inhibitor-7

• 常用名: PI3K/mTOR Inhibitor-7
• 英文名: PI3K/mTOR Inhibitor-7
• CAS号: 2456295-65-9
• 分子量: 571.63
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₃N₉O₄
• 熔点: N/A
• 闪点: N/A

PI3K/mTOR Inhibitor-7用途

PI3K/mTOR抑制剂-7(化合物19i)是一种有效的PI3K/mTOR双重抑制剂。PI3K/mTOR抑制剂-7的效价是阳性对照gedatolisib的4.7倍(0.3 vs.1.4μM,IC50值)。PI3K/mTOR抑制剂-7可显著抑制10μM下的PI3K/Akt/mTOR信号通路。PI3K/mTOR抑制剂-7具有研究癌症疾病的潜力[1]。

PI3K/mTOR Inhibitor-7名称

• 英文名: PI3K/mTOR Inhibitor-7

PI3K/mTOR Inhibitor-7生物活性

• 描述: PI3K/mTOR抑制剂-7(化合物19i)是一种有效的PI3K/mTOR双重抑制剂。PI3K/mTOR抑制剂-7的效价是阳性对照gedatolisib的4.7倍(0.3 vs.1.4μM,IC50值)。PI3K/mTOR抑制剂-7可显著抑制10μM下的PI3K/Akt/mTOR信号通路。PI3K/mTOR抑制剂-7具有研究癌症疾病的潜力[1]。
• 相关类别:
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> mTOR
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 参考文献:

  [1]. Wang L, et al. Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors. Eur J Med Chem. 2020 Oct 15;204:112637

PI3K/mTOR Inhibitor-7物理化学性质

• 分子式: C₂₉H₃₃N₉O₄
• 分子量: 571.63

PI3K/mTOR Inhibitor-7靶点实验

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实验名称：Inhibition of PI3K/mTOR signaling in human HCT116 cells assessed as reduction in p705... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772826

实验名称：Metabolic stability in artificial gastrointestinal fluids 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772827

实验名称：Antiproliferative activity against human MCF-7 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4772824

实验名称：Inhibition of PI3K/mTOR signaling in human HCT116 cells assessed as reduction in AKT ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772825

实验名称：Metabolic stability in rat liver microsomes assessed as compound remaining measured a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772828

实验名称：Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after 1 hr ... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform External Id：CHEMBL4772818

实验名称：Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in ce... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4772819

实验名称：Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate measured after 1 hr i... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform External Id：CHEMBL4772816

实验名称：Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate measured after 1 hr ... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform External Id：CHEMBL4772817

实验名称：Antiproliferative activity against human HCT116 cells assessed as reduction in cell v... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4772822

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