Antitumor agent-62

• 常用名: Antitumor agent-62
• 英文名: Antitumor agent-62
• CAS号: 2460735-29-7
• 分子量: 489.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₉N₃O₉S
• 熔点: N/A
• 闪点: N/A

Antitumor agent-62用途

抗肿瘤剂-62(化合物47)是一种不释放的抗肿瘤剂。抗肿瘤剂-62对四种癌细胞系显示出抗增殖活性。抗肿瘤药物-62激活线粒体凋亡途径并在G2/M期阻滞细胞周期[1]。

Antitumor agent-62名称

• 英文名: Antitumor agent-62

Antitumor agent-62生物活性

• 描述: 抗肿瘤剂-62(化合物47)是一种不释放的抗肿瘤剂。抗肿瘤剂-62对四种癌细胞系显示出抗增殖活性。抗肿瘤药物-62激活线粒体凋亡途径并在G2/M期阻滞细胞周期[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 体外研究: 抗肿瘤剂-62(化合物47)对MDA-MB-231、MCF-7、HepG2、A549和LO2细胞显示出抗增殖活性,IC50值分别为1.23±0.10、1.91±0.14、2.81±0.13、4.18±0.15和9.16±0.38μM【1】。
• 参考文献:

  [1]. Shi Z, et al. Novel NO-releasing scopoletin derivatives induce cell death via mitochondrial apoptosis pathway and cell cycle arrest. Eur J Med Chem. 2020 Aug 15;200:112386.

Antitumor agent-62物理化学性质

• 分子式: C₂₁H₁₉N₃O₉S
• 分子量: 489.46

Antitumor agent-62靶点实验

查看更多实验

实验名称：Anticancer activity against human A549 cells assessed as inhibition of cell prolifera... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4770466

实验名称：Cytotoxicity against human L02 cells assessed as reduction in cell viability measured... 来源：ChEMBL 靶标：L02 External Id：CHEMBL4770467

实验名称：Anticancer activity against human MCF7 cells assessed as inhibition of cell prolifera... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4770464

实验名称：Anticancer activity against human HepG2 cells assessed as inhibition of cell prolifer... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770465

实验名称：Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of c... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4770470

实验名称：Antiproliferative activity in human MDA-MB-231 cells assessed as inhibition of cell v... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4770471

实验名称：Prodrug release in human MDA-MB-231 cells assessed as increase in intracellular NO le... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4770468

实验名称：Antiproliferative activity against human MCF7 cells assessed as inhibition of cell gr... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4770462

实验名称：Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell pro... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4770463

实验名称：Inhibition of colony formation in human MDA-MB-231 cells assessed as fewer and smalle... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4770460

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