伐尼克兰

• 常用名: 伐尼克兰
• 英文名: Varenicline
• CAS号: 249296-44-4
• 分子量: 211.26
• 密度: 1.247g/cm3
• 沸点: 400.6ºC at 760mmHg
• 分子式: C₁₃H₁₃N₃
• 熔点: N/A
• 闪点: 196.1ºC

伐尼克兰名称

• 中文名: 伐伦克林
• 英文名: varenicline
• 中文别名: 7,8,9,10-四氢-6,10-亚甲基-6H-吡嗪并[2,3-h][3]苯并氮杂卓 | 瓦伦尼克林 | 伐尼克兰

伐尼克兰生物活性

• 相关类别:
  信号通路 >> 跨膜转运 >> 胆碱受体
  信号通路 >> 神经信号通路 >> 胆碱受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kikkawa, H.; Maruyama, N.; Fujimoto, Y.; Hasunuma, T. Single- and multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy Japanese adult smokers. Journal of Clinical Pharmacology (2011), 51(4), 527-537.

  [2]. Bordia T, Hrachova M, Chin M et al. Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34.

  [3]. Pachas GN, Cather C, Pratt SA et al. Varenicline for Smoking Cessation in Schizophrenia: Safety and Effectiveness in a 12-Week, Open-Label Trial. J Dual Diagn. 2012;8(2):117-125.

  [4]. Krebs P, Sherman SE. Review: Varenicline for tobacco cessation does not increase CV serious adverse events. Ann Intern Med. 2012 Aug 21;157(4):JC2-2.

伐尼克兰物理化学性质

• 密度: 1.247g/cm3
• 沸点: 400.6ºC at 760mmHg
• 分子式: C₁₃H₁₃N₃
• 分子量: 211.26
• 闪点: 196.1ºC
• PSA: 152.87000
• LogP: 0.01010
• InChIKey: JQSHBVHOMNKWFT-UHFFFAOYSA-N
• SMILES: c1cnc2cc3c(cc2n1)C1CNCC3C1
• 蒸汽压: 1.25E-06mmHg at 25°C
• 折射率: 1.667
• 储存条件: 2-8℃

伐尼克兰靶点实验

查看更多实验

实验名称：Antagonist activity at human alpha3beta4 nAChR expressed in human SH-SY5Y cells asses... 来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-3 External Id：CHEMBL2188158

实验名称：Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed ... 来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-7 External Id：CHEMBL2168691

实验名称：Agonist activity at human alpha3beta4 nAChR expressed in human SH-SY5Y cells assessed... 来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-3 External Id：CHEMBL2188159

实验名称：Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes asse... 来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit beta-4 External Id：CHEMBL2168692

实验名称：Antagonist activity at human alpha1beta1gammadelta nAChR expressed in human TE671/RD ... 来源：ChEMBL 靶标：Acetylcholine receptor subunit alpha External Id：CHEMBL2188156

实验名称：Agonist activity at human alpha1beta1gammadelta nAChR expressed in human TE671/RD cel... 来源：ChEMBL 靶标：Acetylcholine receptor subunit alpha External Id：CHEMBL2188157

实验名称：Displacement of [3H]-Epibatidine from rat alpha2beta2 nACHR expressed in HEK293 cell ... 来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit beta-2 External Id：CHEMBL2330772

实验名称：Antinociception activity in mouse assessed as reaction time taken for jumping or lick... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2168683

实验名称：Antinociception activity in mouse at 10 mg/kg, sc after 5 mins by tail-flick method 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2168684

实验名称：Antinociceptive activity in sc dosed mouse assessed as inhibition of nicotine-induced... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3610676

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伐尼克兰英文别名

• Vareniclene
• Chantix
• 10-tetrahydro
• 10-Methano-6H-pyrazino[2
• 5,8,14-triazatetracycIo[10.3.1.0(2,11).0(4,9)]hexadeca-2(11),3,5,7,9-pentaene
• 5,8,14-triazatetracyclo[10.3.1.0(2,11),0(4,9)]hexadeca-2(l11),3,5,7,9-pentaene
• 3-h][3]benzazepine
• 5,8,14-triazatetracyclo[10.3.1.0(2,11).0(4,9)]hexadeca-2(11),3,5,7,9-pentaene
• Varenicline
• 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine
• Unii-W6hs99o8zo