AZD7545

• 常用名: AZD7545
• 英文名: AZD-7547
• CAS号: 252017-04-2
• 分子量: 478.870
• 密度: 1.5±0.1 g/cm3
• 沸点: 683.1±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈ClF₃N₂O₅S
• 熔点: N/A
• 闪点: 366.9±31.5 °C

AZD7545用途

AZD7545是PDHK抑制剂,对PDHK1和PDHK2的IC50分别为36.8 nM和6.4 nM。

AZD7545名称

• 中文名: 4-[[3-氯-4-[[(2R)-3,3,3-三氟-2-羟基-2-甲基-1-氧代丙基]氨基]苯基]磺酰基]-N,N-二甲基苯甲酰胺
• 英文名: (2,4-Dihydroxy-5-isopropylphenyl){5-[(4-methyl-1-piperazinyl)meth yl]-1,3-dihydro-2H-isoindol-2-yl}methanone

AZD7545生物活性

• 描述: AZD7545是PDHK抑制剂,对PDHK1和PDHK2的IC50分别为36.8 nM和6.4 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> PDHK
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Morrell JA, et al. AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. Biochem Soc Trans. 2003 Dec;31(Pt 6):1168-70.

  [2]. Mayers RM, et al. AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1165-7.

AZD7545物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 683.1±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈ClF₃N₂O₅S
• 分子量: 478.870
• 闪点: 366.9±31.5 °C
• 精确质量: 478.057709
• PSA: 67.25000
• LogP: 2.66
• InChIKey: DTDZLJHKVNTQGZ-GOSISDBHSA-N
• SMILES: CN(C)C(=O)c1ccc(S(=O)(=O)c2ccc(NC(=O)C(C)(O)C(F)(F)F)c(Cl)c2)cc1
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.573
• 储存条件: -20℃

AZD7545安全信息

• 危害码 (欧洲): Xi

AZD7545靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Anticancer activity against human A549 cells assessed as reduction in cell growth at ... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5538421

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

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AZD7545英文别名

• 4-[(3-Chloro-4-{[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino}phenyl)sulfonyl]-N,N-dimethylbenzamide
• (R)-N-[2-Chloro-4-(4-mesylphenylsulphinyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
• (4R)-3-[(2E)-1-Oxo-2-penten-1-yl]-4-phenyl-2-oxazolidinone
• (4R)-3-[(2E)-1-Oxo-2-pentenyl]-4-phenyl-2-oxazolidinone
• (R)-N-{2-Chloro-4-[4-(N,N-dimethylcarbamoyl)phenylsulphonyl]phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
• (R)-N-[(E)-EtCHCHC(O)]-4-phenyl-1,3-oxazolidin-2-one
• AZD-7547
• AZD7545