AR-C102222

• 常用名: AR-C102222
• 英文名: AR-C102222
• CAS号: 253771-21-0
• 分子量: 418.828
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₇ClF₂N₆O
• 熔点: N/A
• 闪点: N/A

AR-C102222用途

AR-C102222 是一种螺环氟哌啶喹唑啉选择性 iNOS 抑制剂。 AR-C102222可用于神经病理性疼痛的研究。

AR-C102222名称

• 英文名: 5-[(4'-Amino-5',8'-difluoro-1H,1'H-spiro[piperidine-4,2'-quinazolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride (1:1)

AR-C102222生物活性

• 描述: AR-C102222 是一种螺环氟哌啶喹唑啉选择性 iNOS 抑制剂。 AR-C102222可用于神经病理性疼痛的研究。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Chris Walpole, et al. Diastereoselective synthesis of fluorinated piperidine quinazoline spirocycles as iNOS selective inhibitors. Tetrahedron Letters. Volume 53, Issue 24, 13 June 2012, Pages 2942-2947.

AR-C102222物理化学性质

• 分子式: C₁₉H₁₇ClF₂N₆O
• 分子量: 418.828
• 精确质量: 418.112030
• InChIKey: FJFMOBYDHGJDGV-UHFFFAOYSA-N
• SMILES: Cl.N#Cc1ccc(C(=O)N2CCC3(CC2)N=C(N)c2c(F)ccc(F)c2N3)cn1

AR-C102222靶点实验

查看更多实验

实验名称：Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide production 来源：ChEMBL 靶标：Nitric oxide synthase, inducible External Id：CHEMBL1763172

实验名称：Lipophilicity, log D of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1763171

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Inhibition of human eNOS expressed in insect SF9 cells at 10 uM after 1 hr 来源：ChEMBL 靶标：Nitric oxide synthase, endothelial External Id：CHEMBL946896

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Metabolic stability in human microsomes assessed as per mg of tissue 来源：ChEMBL 靶标：N/A External Id：CHEMBL1763166

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Metabolic stability in human hepatocytes assessed as per 10'6 cells 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL1763165

实验名称：Volume of distribution at steady state in iv dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1763168

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AR-C102222英文别名

• 2-Pyridinecarbonitrile, 5-[(4'-amino-5',8'-difluorospiro[piperidine-4,2'(1'H)-quinazolin]-1-yl)carbonyl]-, hydrochloride (1:1)
• 5-[(4'-Amino-5',8'-difluoro-1H,1'H-spiro[piperidine-4,2'-quinazolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride (1:1)