珊瑚菜素

• 常用名: 珊瑚菜素
• 英文名: Phellopterin
• CAS号: 2543-94-4
• 分子量: 300.306
• 密度: 1.2±0.1 g/cm3
• 沸点: 480.4±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆O₅
• 熔点: 102-103ºC
• 闪点: 244.4±28.7 °C

珊瑚菜素用途

Phellopterin 是从 P. trifoliata 中分离得到的天然产物。Phellopterin 通过调节 Akt 和 PKC 通路降低 TNF-alpha 诱导的 VCAM-1 表达,从而抑制单核细胞与内皮细胞的粘附。

珊瑚菜素名称

• 中文名: 珊瑚菜素
• 英文名: 4-methoxy-9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one
• 中文别名: 珊瑚菜内酯

珊瑚菜素生物活性

• 描述: Phellopterin 是从 P. trifoliata 中分离得到的天然产物。Phellopterin 通过调节 Akt 和 PKC 通路降低 TNF-alpha 诱导的 VCAM-1 表达,从而抑制单核细胞与内皮细胞的粘附。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Nizamutdinova IT, et al. Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells. Int Immunopharmacol. 2008 May;8(5):670-8.

珊瑚菜素物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 480.4±45.0 °C at 760 mmHg
• 熔点: 102-103ºC
• 分子式: C₁₇H₁₆O₅
• 分子量: 300.306
• 闪点: 244.4±28.7 °C
• 精确质量: 300.099762
• PSA: 61.81000
• LogP: 4.19
• InChIKey: BMLZFLQMBMYVHG-UHFFFAOYSA-N
• SMILES: COc1c2ccoc2c(OCC=C(C)C)c2oc(=O)ccc12
• 外观性状: 粉末
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.592
• 储存条件: 2-8℃，干燥，密闭

珊瑚菜素安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2932999099

珊瑚菜素海关

• 海关编码: 2932999099
• 中文概述: 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

珊瑚菜素靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

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珊瑚菜素英文别名

• Phellopterin
• 4-Methoxy-9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
• 4-Methoxy-9-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
• 4-Methoxy-9-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g]chromen-7-one
• fellopterin
• Phelloterin
• 5-methoxy-8-prenyloxypsoralen