Ascochlorin A

• 常用名: Ascochlorin A
• 英文名: Ascochlorin A
• CAS号: 2550720-02-8
• 分子量: 406.94
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₃₁ClO₄
• 熔点: N/A
• 闪点: N/A

Ascochlorin A用途

抗坏血酸A是一种新型有效的hDHODH抑制剂(KD=3.29μM),用于治疗三阴性乳腺癌。

Ascochlorin A名称

• 英文名: Ascochlorin A

Ascochlorin A生物活性

• 描述: 抗坏血酸A是一种新型有效的hDHODH抑制剂(KD=3.29μM),用于治疗三阴性乳腺癌。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
• 参考文献:

  [1]. Luo X, et al. Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer. J Med Chem. 2021 Sep 23;64(18):13918-13932.

Ascochlorin A物理化学性质

• 分子式: C₂₃H₃₁ClO₄
• 分子量: 406.94
• InChIKey: HQKVWXLIBNKFCS-OEAGFLSSSA-N
• SMILES: C=C1CCC(O)C(C)(C)C1CCC(C)=CCc1c(O)c(Cl)c(C)c(C=O)c1O

Ascochlorin A靶点实验

查看更多实验

实验名称：Inhibition of DHODH in human MDA-MB-468 cells assessed as downregulation of CTP metab... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL4833360

实验名称：Inhibition of DHODH in human MDA-MB-468 cells assessed as downregulation of UDP metab... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL4833359

实验名称：Inhibition of DHODH in human MDA-MB-468 cells assessed as downregulation of UMP metab... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL4833358

实验名称：Inhibition of DHODH in human MDA-MB-468 cells assessed as upregulation of orotate met... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL4833357

实验名称：Antitumor activity against patient-derived breast cancer cells xenografted in NOD/SCI... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4833362

实验名称：Antitumor activity against patient-derived breast cancer cells xenografted in NOD/SCI... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4833361

实验名称：Inhibition of cell proliferation in human MDA-MB-231 cells at <=10 uM incubated for 4... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4833352

实验名称：Induction of apoptosis in human MDA-MB-468 cells assessed as increase in cleaved casp... 来源：ChEMBL 靶标：MDA-MB-468 External Id：CHEMBL4833351

实验名称：Induction of apoptosis in human MDA-MB-231 cells assessed as increase in cleaved casp... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4833350

实验名称：Induction of apoptosis in human MDA-MB-468 cells assessed as increase in cleaved PARP... 来源：ChEMBL 靶标：MDA-MB-468 External Id：CHEMBL4833349

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