mGAT-IN-1

• 常用名: mGAT-IN-1
• 英文名: mGAT-IN-1
• CAS号: 2556833-08-8
• 分子量: 544.17
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₄ClN₃O₂S₂
• 熔点: N/A
• 闪点: N/A

mGAT-IN-1用途

mGAT-IN-1(化合物28)是一种有效的非选择性GAT抑制剂。mGAT-IN-1对mGAT3有很高的抑制效力,IC50为2.5μM,pIC50为5.61【1】。

mGAT-IN-1名称

• 英文名: mGAT-IN-1

mGAT-IN-1生物活性

• 描述: mGAT-IN-1(化合物28)是一种有效的非选择性GAT抑制剂。mGAT-IN-1对mGAT3有很高的抑制效力,IC50为2.5μM,pIC50为5.61【1】。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 靶点实验:

  IC50: 2.5 μM (mGAT3); pIC50: 5.06 ± 0.02 (mGAT1), 5.35 ± 0.08 (mGAT2), 5.61 ± 0.07 (mGAT3), 5.21 ± 0.05 (mGAT4)[1]

• 参考文献:

  [1]. Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.

mGAT-IN-1物理化学性质

• 分子式: C₂₈H₃₄ClN₃O₂S₂
• 分子量: 544.17

mGAT-IN-1靶点实验

查看更多实验

实验名称：Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition o... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 3 External Id：CHEMBL4838587

实验名称：Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 3 External Id：CHEMBL4767558

实验名称：Inhibition of mouse GAT2 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 2 External Id：CHEMBL4767559

实验名称：Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 3 External Id：CHEMBL4767588

实验名称：Lipophilicity, logP of the compound by UPLC-MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767573

实验名称：Displacement of [3H]NO711 from mouse GAT1 expressed in HEK293 cells at 100 uM measure... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 1 External Id：CHEMBL4767589

实验名称：Inhibition of mouse GAT1 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 1 External Id：CHEMBL4767560

实验名称：Inhibition of mouse GAT1 expressed in human HEK293 cell line assessed as inhibition o... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 1 External Id：CHEMBL4838580

实验名称：Inhibition of mouse GAT3 expressed in human HEK293 cell line assessed as inhibition o... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 3 External Id：CHEMBL4838586

实验名称：Inhibition of mouse GAT2 expressed in human HEK293 cell line assessed as inhibition o... 来源：ChEMBL 靶标：Sodium- and chloride-dependent betaine transporter External Id：CHEMBL4838585

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