mGAT3/4-IN-2

• 常用名: mGAT3/4-IN-2
• 英文名: mGAT3/4-IN-2
• CAS号: 2556833-68-0
• 分子量: 502.13
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₂ClN₃OS₂
• 熔点: N/A
• 闪点: N/A

mGAT3/4-IN-2用途

mGAT3/4-IN-2(化合物27b)是一种有效的mGAT3/mGAT4抑制剂,pIC50值分别为5.44和5.25【1】。

mGAT3/4-IN-2名称

• 英文名: mGAT3/4-IN-2

mGAT3/4-IN-2生物活性

• 描述: mGAT3/4-IN-2(化合物27b)是一种有效的mGAT3/mGAT4抑制剂,pIC50值分别为5.44和5.25【1】。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 代谢疾病
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 靶点实验:

  pIC50: 5.12 ± 0.08 (mGAT1), 5.14 ± 0.07 (mGAT2), 5.44 ± 0.08 (mGAT3), 5.25 ± 0.04 (mGAT4)[1]

• 参考文献:

  [1]. Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.

mGAT3/4-IN-2物理化学性质

• 分子式: C₂₆H₃₂ClN₃OS₂
• 分子量: 502.13

mGAT3/4-IN-2靶点实验

查看更多实验

实验名称：Displacement of [3H]NO711 from mouse GAT1 expressed in HEK293 cells measured after 40... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 1 External Id：CHEMBL4767586

实验名称：Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 3 External Id：CHEMBL4767558

实验名称：Inhibition of mouse GAT2 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 2 External Id：CHEMBL4767559

实验名称：Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 3 External Id：CHEMBL4767588

实验名称：Lipophilicity, logP of the compound by UPLC-MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767573

实验名称：Inhibition of mouse GAT1 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 1 External Id：CHEMBL4767560

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