BTK inhibitor 19

• 常用名: BTK inhibitor 19
• 英文名: BTK inhibitor 19
• CAS号: 2557174-19-1
• 分子量: 527.50
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₄F₃N₇O₃
• 熔点: N/A
• 闪点: N/A

BTK inhibitor 19用途

BTK抑制剂19是一种高选择性共价BTK抑制剂(IC50=2.7 nM)。

BTK inhibitor 19名称

• 英文名: BTK inhibitor 19

BTK inhibitor 19生物活性

• 描述: BTK抑制剂19是一种高选择性共价BTK抑制剂(IC50=2.7 nM)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> BTK
• 参考文献:

  [1]. Ma C, et al. Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitors. J Med Chem. 2021 Nov 11;64(21):16242-16270.

BTK inhibitor 19物理化学性质

• 分子式: C₂₅H₂₄F₃N₇O₃
• 分子量: 527.50
• InChIKey: WIZIQUFUGUEWKY-KRWDZBQOSA-N
• SMILES: C=CC(=O)N1CCCCC1c1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c(C(N)=O)n1N

BTK inhibitor 19靶点实验

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实验名称：Receptor occupancy at BTK in spleen of ICR mouse at 15 mg/kg, po after 24 hrs by ELIS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4841651

实验名称：Receptor occupancy at BTK in PBMC of ICR mouse at 15 mg/kg, po after 24 hrs by ELISA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4841650

实验名称：Toxicity in SFP CD-1 mouse assessed as change in temperature at 10 to 1280 mg/kg, po ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4841656

实验名称：Toxicity in SFP CD-1 mouse assessed as pathological change in visceral organs at 10 t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4841655

实验名称：Receptor occupancy at BTK in spleen of ICR mouse at 15 mg/kg, po after 1 hr by ELISA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4841654

实验名称：Receptor occupancy at BTK in PBMC of ICR mouse at 15 mg/kg, po after 1 hr by ELISA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4841653

实验名称：AUC(0 to 8 hrs) in CB-17 SCID mouse xenografted with human TMD8 cells at 7.5 mg/kg, p... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4841708

实验名称：Inhibition of BTK in human TMD8 cells assessed as reduction in PLCgamma2 phosphorylat... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4841705

实验名称：Toxicity in CB-17 SCID mouse xenografted with human TMD8 cells assessed as change in ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4841712

实验名称：Antitumor activity against human TMD8 cells xenografted in CB-17 SCID nude mouse asse... 来源：ChEMBL 靶标：TMD8 External Id：CHEMBL4841711

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