GNF2133

• 常用名: GNF2133
• 英文名: GNF2133
• CAS号: 2561414-56-8
• 分子量: 434.53
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₀N₆O₂
• 熔点: N/A
• 闪点: N/A

GNF2133用途

GNF2133是一种选择性DYRK1A抑制剂,IC50值为6 nM。

GNF2133名称

• 英文名: GNF2133

GNF2133生物活性

• 描述: GNF2133是一种选择性DYRK1A抑制剂,IC50值为6 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> DYRK
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Liu YA, et al. Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133. J Med Chem. 2020 Mar 26;63(6):2958-2973.

GNF2133物理化学性质

• 分子式: C₂₄H₃₀N₆O₂
• 分子量: 434.53
• InChIKey: SAZIAQSVBIWIDU-UHFFFAOYSA-N
• SMILES: CCN1CCN(C(=O)Nc2cc(-c3cn(C4CCOCC4)c4cnccc34)ccn2)CC1
• 储存条件: 2-8°C，密封，干燥

GNF2133靶点实验

查看更多实验

实验名称：In vivo induction of proliferation of beta cells in Wistar Han rat assessed as increa... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4605009

实验名称：Inhibition of RIPK2 (unknown origin) at 2 uM caliper microfluidic kinase assay relati... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 2 External Id：CHEMBL4604987

实验名称：Phototoxicity in mouse 3T3 clone A31 cells incubated for 1 hr followed by stimulated ... 来源：ChEMBL 靶标：NIH3T3 External Id：CHEMBL4604986

实验名称：Inhibition of CLK2 (unknown origin) at 2 uM caliper microfluidic kinase assay relativ... 来源：ChEMBL 靶标：Dual specificity protein kinase CLK2 External Id：CHEMBL4604989

实验名称：Inhibition of CLK1 (unknown origin) at 2 uM caliper microfluidic kinase assay relativ... 来源：ChEMBL 靶标：Dual specificity protein kinase CLK1 External Id：CHEMBL4604988

实验名称：Inhibition of CLK4 (unknown origin) at 2 uM caliper microfluidic kinase assay relativ... 来源：ChEMBL 靶标：Dual specificity protein kinase CLK4 External Id：CHEMBL4604990

实验名称：Effective permeability of compound by PAMPA assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604983

实验名称：Genotoxicity in human TK6 cells by micronucleus test 来源：ChEMBL 靶标：TK6 External Id：CHEMBL4604985

实验名称：Mutagenicity in Salmonella typhimurium by Ames test 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604984

实验名称：Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 1 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604971

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