Antitumor agent-110

更新时间：2025-11-25 10:46:20

Antitumor agent-110用途

抗癌剂-110(化合物13)是一种具有良好渗透性的抗癌咪唑并四嗪。抗肿瘤药物-110在G2/M期阻断细胞cycel,并诱导细胞凋亡[1]。

英文名	Antitumor agent-110

描述	抗癌剂-110(化合物13)是一种具有良好渗透性的抗癌咪唑并四嗪。抗肿瘤药物-110在G2/M期阻断细胞cycel,并诱导细胞凋亡[1]。
相关类别	信号通路 >> 细胞凋亡 >> 细胞凋亡研究领域 >> 癌症
参考文献	[1]. Summers HS, et al. Discovery of new imidazotetrazinones with potential to overcome tumor resistance. Eur J Med Chem. 2023 Sep 5;257:115507.

分子式	C₁₀H₆N₆OS
分子量	258.26
InChIKey	SDRJGLKNGWVTJR-UHFFFAOYSA-N
SMILES	C#CCn1nnc2c(-c3nccs3)ncn2c1=O

实验名称：Inhibition of cell colony formation in MMR-deficient human HCT-116 cells assessed as ...
来源：ChEMBL
靶标：HCT-116
External Id：CHEMBL5336433

实验名称：Inhibition of cell colony formation in human U373V cells assessed as reduction in clo...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5336431

实验名称：Inhibition of cell colony formation in MGMT-expressing human U373M cells assessed as ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5336432

实验名称：Selectivity ratio of GI50 for cytotoxicity against human MRC5 cells to GI50 for antip...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5336429

实验名称：Antiproliferative activity against MMR-deficient human HCT-116 cells assessed as inhi...
来源：ChEMBL
靶标：HCT-116
External Id：CHEMBL5336427

实验名称：Antiproliferative activity against human U373V cells assessed as inhibition of cell g...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5336425

实验名称：Antiproliferative activity against MGMT-expressing human U373M cells assessed as inhi...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5336426

实验名称：Stability of the compound in phosphate buffered saline at pH 7.4 by 1H NMR spectrosco...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5336471

实验名称：Stability of the compound in phosphate buffered saline at pH 5.5 by 1H NMR spectrosco...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5336472

实验名称：Ratio of permeability across dog MDCK cells transfected with MDR1 to permeability acr...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5336465

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