Antimicrobial agent-1

• 常用名: Antimicrobial agent-1
• 英文名: Antimicrobial agent-1
• CAS号: 2579696-45-8
• 分子量: 391.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₁N₃O₂S
• 熔点: N/A
• 闪点: N/A

Antimicrobial agent-1用途

抗菌剂-1(化合物6C)对TolC突变大肠杆菌具有较强的抗菌活性,MIC值为2μg/mL。抗菌剂-1和粘菌素对革兰氏阴性菌具有协同作用。抗菌剂-1对哺乳动物细胞系无细胞毒性,MIC＞128 Caco-2和Vero细胞系中的μg/mL【1】。

Antimicrobial agent-1名称

• 英文名: Antimicrobial agent-1

Antimicrobial agent-1生物活性

• 描述: 抗菌剂-1(化合物6C)对TolC突变大肠杆菌具有较强的抗菌活性,MIC值为2μg/mL。抗菌剂-1和粘菌素对革兰氏阴性菌具有协同作用。抗菌剂-1对哺乳动物细胞系无细胞毒性,MIC＞128 Caco-2和Vero细胞系中的μg/mL【1】。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  IC50: 2 μg/mL (TolC mutant E. coli)[1]

• 参考文献:

  [1]. Dokla EME, et al. Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. Eur J Med Chem. 2020;186:111850.

Antimicrobial agent-1物理化学性质

• 分子式: C₂₂H₂₁N₃O₂S
• 分子量: 391.49

Antimicrobial agent-1靶点实验

查看更多实验

实验名称：Synergistic antibacterial activity against Klebsiella pneumoniae ATCC 1706 in presenc... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4682323

实验名称：Synergistic antibacterial activity against wild type Escherichia coli BW25113 in pres... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4682322

实验名称：Synergistic antibacterial activity against Acinetobacter baumannii ATCC 19606 in pres... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL4682325

实验名称：Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 18 to... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL4682324

实验名称：Synergistic antibacterial activity against Pseudomonas aeruginosa ATCC 15442 in prese... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4682327

实验名称：Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 incubated for 18 to ... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4682326

实验名称：Cytotoxicity against African green monkey Vero cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：Vero External Id：CHEMBL4682329

实验名称：Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability incub... 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL4682328

实验名称：Antibacterial activity against Escherichia coli tolC mutant incubated for 24 hrs by b... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5356213

实验名称：Antimicrobial activity against Escherichia coli JW55031 TolC mutant assessed as reduc... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4682317

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