Dot1L-IN-7

• 常用名: Dot1L-IN-7
• 英文名: Dot1L-IN-7
• CAS号: 2580940-76-5
• 分子量: 461.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₇N₉O₂
• 熔点: N/A
• 闪点: N/A

Dot1L-IN-7用途

Dot1L-IN-7(化合物25)是端粒沉默1样蛋白(Dot1L)抑制剂的有效和选择性干扰剂,IC50为1.0μM。Dot1L-IN-7选择性杀死混合系白血病(MLL)-AF9,对E2A-HLF细胞的生长没有任何影响【1】。

Dot1L-IN-7名称

• 英文名: Dot1L-IN-7

Dot1L-IN-7生物活性

• 描述: Dot1L-IN-7(化合物25)是端粒沉默1样蛋白(Dot1L)抑制剂的有效和选择性干扰剂,IC50为1.0μM。Dot1L-IN-7选择性杀死混合系白血病(MLL)-AF9,对E2A-HLF细胞的生长没有任何影响【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
• 靶点实验:

  DOT1L:1 μM (IC50)

• 参考文献:

  [1]. Garrett S Gibbons, et al. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Eur J Med Chem. 2020 Mar 1;189:112023.

Dot1L-IN-7物理化学性质

• 分子式: C₂₃H₂₇N₉O₂
• 分子量: 461.52

Dot1L-IN-7靶点实验

查看更多实验

实验名称：Antiproliferative activity against mouse bone marrow cell transformed with E2A-HLF as... 来源：ChEMBL 靶标：Bone marrow cell External Id：CHEMBL4684507

实验名称：Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 as... 来源：ChEMBL 靶标：Bone marrow cell External Id：CHEMBL4684506

实验名称：Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed... 来源：ChEMBL 靶标：Histone H3 methyltransferase DOT1 variant d External Id：CHEMBL4684509

实验名称：Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed... 来源：ChEMBL 靶标：Histone H3 methyltransferase DOT1 variant d External Id：CHEMBL4684508

实验名称：Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed... 来源：ChEMBL 靶标：Histone H3 methyltransferase DOT1 variant d External Id：CHEMBL4684511

实验名称：Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed... 来源：ChEMBL 靶标：Histone H3 methyltransferase DOT1 variant d External Id：CHEMBL4684510

实验名称：Induction of cell differentiation in mouse bone marrow cells transformed with MLL-AF9... 来源：ChEMBL 靶标：Bone marrow cell External Id：CHEMBL4684513

实验名称：Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed... 来源：ChEMBL 靶标：Histone H3 methyltransferase DOT1 variant d External Id：CHEMBL4684512

实验名称：Binding affinity to recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues)... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase, H3 lysine-79 specific External Id：CHEMBL4684501

实验名称：Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 as... 来源：ChEMBL 靶标：Bone marrow cell External Id：CHEMBL4684502

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