印苦楝内酯

更新时间：2025-08-22 14:42:54

印苦楝内酯结构式	常用名	印苦楝内酯	英文名	Nimbolide
	CAS号	25990-37-8	分子量	466.52
	密度	1.3±0.1 g/cm3	沸点	608.6±55.0 °C at 760 mmHg
	分子式	C₂₇H₃₀O₇	熔点	N/A
	MSDS	中文版美版	闪点	321.9±31.5 °C
	符号	GHS07	信号词	Warning

印苦楝内酯用途

Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。

中文名	Nimbolide
英文名	Nimbolide
英文别名	更多

描述	Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> CDK
靶点实验	NF-κB CDK4 CDK6
参考文献	[1]. Bodduluru LN, et al. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol In Vitro. 2014 Aug;28(5):1026-35.

密度	1.3±0.1 g/cm3
沸点	608.6±55.0 °C at 760 mmHg
分子式	C₂₇H₃₀O₇
分子量	466.52
闪点	321.9±31.5 °C
精确质量	466.199158
PSA	92.04000
LogP	2.66
InChIKey	JZIQWNPPBKFOPT-LSYMHUITSA-N
SMILES	COC(=O)CC1C2(C)C3=C(C)C(c4ccoc4)CC3OC2C2OC(=O)C3(C)C=CC(=O)C1(C)C23
蒸汽压	0.0±1.7 mmHg at 25°C
折射率	1.597
储存条件	-20°C，干燥，密封

印苦楝内酯毒性英文版

符号	GHS07
信号词	Warning
危害声明	H302
警示性声明	P301 + P312 + P330
危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport
RTECS号	GY2370000

Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma.

Int. J. Mol. Sci. 16 , 23405-24, (2015)

Osteosarcoma (OS) is a primary malignant tumor of bone and is most prevalent in children and adolescents. OS is frequently associated with pulmonary metastasis, which is the main cause of OS-related m...

Nimbolide, a constituent of Azadirachta indica, inhibits Plasmodium falciparum in culture.

Southeast Asian J. Trop. Med. Public Health 16(1) , 66-72, (1985)

The terpenoid lactone nimbolide, the structure of which has been unambiguously established, was found to inhibit Plasmodium falciparum in culture with a moderate potency. The EC50 against the parasite...

Induction of cell cycle arrest, DNA damage, and apoptosis by nimbolide in human renal cell carcinoma cells.

Tumour Biol. 36(10) , 7539-47, (2015)

Nimbolide is a tetranortriterpenoid isolated from the leaves and flowers of Azadirachta indica which has been shown to exhibit anticancer, antioxidant, anti-inflammatory, and anti-invasive properties ...

实验名称：Cytotoxicity against human Col2 cells after 72 hrs
来源：ChEMBL
靶标：Col2
External Id：CHEMBL1012114

实验名称：Cytotoxicity against human BC1 cells after 72 hrs
来源：ChEMBL
靶标：NON-PROTEIN TARGET
External Id：CHEMBL1012113

实验名称：Antimalarial activity against Plasmodium falciparum K1
来源：ChEMBL
靶标：Plasmodium falciparum
External Id：CHEMBL1177464

实验名称：Cytotoxicity against mouse P388 cells after 48 hrs
来源：ChEMBL
靶标：P388
External Id：CHEMBL1012119

实验名称：Cytotoxicity against human Lu1 cells
来源：ChEMBL
靶标：Lu1
External Id：CHEMBL1012116

实验名称：Cytotoxicity against human HT1080 cells after 48 hrs
来源：ChEMBL
靶标：HT-1080
External Id：CHEMBL1012115

实验名称：Cytotoxicity against human KB cells after 72 hrs
来源：ChEMBL
靶标：KB
External Id：CHEMBL1012118

实验名称：Cytotoxicity against human SK-MEL-2 cells after 72 hrs
来源：ChEMBL
靶标：SK-MEL-2
External Id：CHEMBL1012117

实验名称：Antiproliferative activity against human HT29 cell line
来源：ChEMBL
靶标：HT-29
External Id：CHEMBL864906

实验名称：Antiproliferative activity against human SW60 cell line
来源：ChEMBL
靶标：SW-60
External Id：CHEMBL866759

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Methyl [8-(3-furyl)-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-yl]acetate

2H,5H-Cyclopenta[d]naphtho[2,3-b:1,8-b'c']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester

(4S,4aS,8aS)-4-(tert-Butyl-dimethylsilyl)oxy-7,7-dimethoxy-4a-methyl-3,4,5,6,8,8a-hexahydro-2H-naphthalen-1-one

(4S,4aS,8aS)-4-(dimethyl-tert-butyl-silyl)oxy-7,7-dimethoxy-4a-methyl-decalin-1-one