印苦楝内酯

更新时间：2024-01-03 17:29:27

印苦楝内酯结构式	常用名	印苦楝内酯	英文名	Nimbolide
	CAS号	25990-37-8	分子量	466.52
	密度	1.3±0.1 g/cm3	沸点	608.6±55.0 °C at 760 mmHg
	分子式	C₂₇H₃₀O₇	熔点	N/A
	MSDS	中文版美版	闪点	321.9±31.5 °C
	符号	GHS07	信号词	Warning

印苦楝内酯用途

Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。

中文名	Nimbolide
英文名	Nimbolide
英文别名	更多

描述	Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> CDK
靶点	NF-κB CDK4 CDK6
参考文献	[1]. Bodduluru LN, et al. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol In Vitro. 2014 Aug;28(5):1026-35.

密度	1.3±0.1 g/cm3
沸点	608.6±55.0 °C at 760 mmHg
分子式	C₂₇H₃₀O₇
分子量	466.52
闪点	321.9±31.5 °C
精确质量	466.199158
PSA	92.04000
LogP	2.66
蒸汽压	0.0±1.7 mmHg at 25°C
折射率	1.597
储存条件	-20°C，干燥，密封

印苦楝内酯毒性英文版

符号	GHS07
信号词	Warning
危害声明	H302
警示性声明	P301 + P312 + P330
危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport
RTECS号	GY2370000

Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma.

Int. J. Mol. Sci. 16 , 23405-24, (2015)

Osteosarcoma (OS) is a primary malignant tumor of bone and is most prevalent in children and adolescents. OS is frequently associated with pulmonary metastasis, which is the main cause of OS-related m...

Nimbolide, a constituent of Azadirachta indica, inhibits Plasmodium falciparum in culture.

Southeast Asian J. Trop. Med. Public Health 16(1) , 66-72, (1985)

The terpenoid lactone nimbolide, the structure of which has been unambiguously established, was found to inhibit Plasmodium falciparum in culture with a moderate potency. The EC50 against the parasite...

Induction of cell cycle arrest, DNA damage, and apoptosis by nimbolide in human renal cell carcinoma cells.

Tumour Biol. 36(10) , 7539-47, (2015)

Nimbolide is a tetranortriterpenoid isolated from the leaves and flowers of Azadirachta indica which has been shown to exhibit anticancer, antioxidant, anti-inflammatory, and anti-invasive properties ...

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